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trypanothione reductase activity

Known as: NADPH2:trypanothione oxidoreductase activity, trypanothione-disulfide reductase activity, trypanothione:NADP+ oxidoreductase activity 
Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide. [EC:1.8.1.12]
National Institutes of Health

Papers overview

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2017
2017
Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.
2015
2015
Novel β-carboline–quinazolinone hybrid as an inhibitor of Leishmania donovani trypanothione reductase: Synthesis, molecular docking and bioevaluation
Trypanothione reductase (TR) is a vital enzyme in the trypanothione based redox metabolism of trypanosomatid parasites. It is one… 
1995
1995
Purification and characterization of a trypanothione-glutathione thioltransferase from Trypanosoma cruzi.
Although trypanothione [T(S)2] is the major thiol component in trypanosomatidae, significant amounts of glutathione are present… 
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