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trimethyllysine dioxygenase activity

Known as: TML-alpha-ketoglutarate dioxygenase activity, trimethyllysine alpha-ketoglutarate dioxygenase activity, TML hydroxylase activity 
Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2… Expand
National Institutes of Health

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Highly Cited
2017
Highly Cited
2017
Background Despite a multiplicity of clinical trials testing immune checkpoint inhibitors, the frequency of expression of… Expand
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2017
2017
Motivation Site directed mutagenesis is widely used to understand the structure and function of biomolecules. Computational… Expand
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Highly Cited
2014
Highly Cited
2014
Mononuclear nonheme iron enzymes generate high-valent iron(IV)-oxo intermediates that effect metabolically important oxidative… Expand
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Highly Cited
2012
Highly Cited
2012
Cell wall catabolism during fruit ripening is under complex control and is key for fruit quality and shelf life. To examine the… Expand
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Highly Cited
2004
Highly Cited
2004
A simple, rapid and accurate method on the basis of solid phase microextraction (SPME) in combination with multicapillary gas… Expand
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Highly Cited
2002
Highly Cited
2002
The benzoate 1,2-dioxygenase system (BZDOS) from Pseudomonas putida mt-2 catalyzes the NADH-dependent oxidation of benzoate to 1… Expand
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Highly Cited
2000
Highly Cited
2000
Avocado (Persea americana Mill. cv Lula) is a climacteric fruit that exhibits a rise in ethylene as the fruit ripens. This rise… Expand
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Review
2000
Review
2000
The abscisic acid (ABA) biosynthetic pathway involves the formation of a 9-cis-epoxycarotenoid precursor. Oxidative cleavage then… Expand
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Highly Cited
1996
Highly Cited
1996
It has been suggested that large-scale climate changes, mostly due to atmospheric injection of greenhouse gases connected with… Expand
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Highly Cited
1983
Highly Cited
1983
Three genetic loci affecting tumor morphology lie within pTiA6NC T-DNA: tms, tmr, and tml. Using deletions and multiple… Expand
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