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trimethyllysine dioxygenase activity

Known as: TML-alpha-ketoglutarate dioxygenase activity, trimethyllysine alpha-ketoglutarate dioxygenase activity, TML hydroxylase activity 
Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2… Expand
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy
Background Despite a multiplicity of clinical trials testing immune checkpoint inhibitors, the frequency of expression of… Expand
Highly Cited
2017
Highly Cited
2017
Analysis and prediction of protein folding energy changes upon mutation by element specific persistent homology
Motivation Site directed mutagenesis is widely used to understand the structure and function of biomolecules. Computational… Expand
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Highly Cited
2014
Highly Cited
2014
Tuning reactivity and mechanism in oxidation reactions by mononuclear nonheme iron(IV)-oxo complexes.
Mononuclear nonheme iron enzymes generate high-valent iron(IV)-oxo intermediates that effect metabolically important oxidative… Expand
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Highly Cited
2012
Highly Cited
2012
Suppression of 9-cis-Epoxycarotenoid Dioxygenase, Which Encodes a Key Enzyme in Abscisic Acid Biosynthesis, Alters Fruit Texture in Transgenic Tomato1[W][OA]
Cell wall catabolism during fruit ripening is under complex control and is key for fruit quality and shelf life. To examine the… Expand
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Highly Cited
2004
Highly Cited
2004
Simultaneous multi-elemental speciation analysis of organometallic compounds by solid-phase microextraction and multicapillary gas chromatography hyphenated to inductively coupled plasma-time-of…
A simple, rapid and accurate method on the basis of solid phase microextraction (SPME) in combination with multicapillary gas… Expand
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Highly Cited
2002
Highly Cited
2002
Benzoate 1,2-dioxygenase from Pseudomonas putida: single turnover kinetics and regulation of a two-component Rieske dioxygenase.
The benzoate 1,2-dioxygenase system (BZDOS) from Pseudomonas putida mt-2 catalyzes the NADH-dependent oxidation of benzoate to 1… Expand
Review
2000
Review
2000
Control of abscisic acid synthesis.
The abscisic acid (ABA) biosynthetic pathway involves the formation of a 9-cis-epoxycarotenoid precursor. Oxidative cleavage then… Expand
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Highly Cited
2000
Highly Cited
2000
Characterization of the 9-cis-epoxycarotenoid dioxygenase gene family and the regulation of abscisic acid biosynthesis in avocado.
Avocado (Persea americana Mill. cv Lula) is a climacteric fruit that exhibits a rise in ethylene as the fruit ripens. This rise… Expand
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Highly Cited
1996
Highly Cited
1996
Global warming and ice ages: I. prospects for physics based modulation of global change
It has been suggested that large-scale climate changes, mostly due to atmospheric injection of greenhouse gases connected with… Expand
Highly Cited
1983
Highly Cited
1983
Multiple mutations in the T region of the Agrobacterium tumefaciens tumor-inducing plasmid.
Three genetic loci affecting tumor morphology lie within pTiA6NC T-DNA: tms, tmr, and tml. Using deletions and multiple… Expand
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