transcriptional preinitiation complex

Known as: DNA-templated transcriptional preinitiation complex, transcription preinitiation complex, preinitiation complex location 
A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a… (More)
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation
Histone modifications regulate chromatin-dependent processes, yet the mechanisms by which they contribute to specific outcomes… (More)
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Review
2010
Review
2010
Transcriptional regulation by p53.
Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function(s) of p53 protein in… (More)
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Highly Cited
2008
Highly Cited
2008
Mediator-dependent recruitment of TFIIH modules in preinitiation complex.
In vitro, without Mediator, the association of general transcription factors (GTF) and RNA polymerase II (Pol II) in… (More)
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Highly Cited
2007
Highly Cited
2007
The positions of TFIIF and TFIIE in the RNA polymerase II transcription preinitiation complex
We incorporated the non-natural photoreactive amino acid p-benzoyl-L-phenylalanine (Bpa) into the RNA polymerase II (Pol II… (More)
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Highly Cited
2005
Highly Cited
2005
mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events
In response to nutrients, energy sufficiency, hormones, and mitogenic agents, S6K1 phosphorylates several targets linked to… (More)
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Highly Cited
2004
Highly Cited
2004
Hierarchical recruitment of polycomb group silencing complexes.
Polycomb group (PcG) proteins maintain the transcriptional silence of target genes through many cycles of cell division. Here, we… (More)
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Highly Cited
2001
Highly Cited
2001
Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules.
Environmental stress-induced phosphorylation of eIF2alpha inhibits protein translation by reducing the availability of eIF2-GTP… (More)
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Highly Cited
1999
Highly Cited
1999
Orientation of the transcription preinitiation complex in archaea.
The basal transcription machinery of Archaea corresponds to the minimal subset of factors required for RNA polymerase II… (More)
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Highly Cited
1998
Highly Cited
1998
Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin.
Cdc45p, a protein essential for initiation of DNA replication, associates with chromatin after "start" in late G1 and during the… (More)
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Highly Cited
1993
Highly Cited
1993
Eukaryotic activators function during multiple steps of preinitiation complex assembly
Eukaryotic activator proteins (activators) stimulate transcription by increasing assembly of the preinitiation complex. We have… (More)
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