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SummaryThe antiarrhythmic efficacy of transcainide has been studied in 41 patients. It abolished ventricular arrhythmias in 10… Expand This study assessed whether class I antiarrhythmic drugs allosterically inhibit [3H]batrachotoxinin A 20-alpha-benzoate ([3H]BTXB… Expand Transcainide, a complex derivative of lidocaine, blocks the open state of BTX-activated sodium channels from bovine heart and rat… Expand The electrophysiology and antiarrhythmic efficacy of R61748, a 4-OH metabolite of R54718 (transcainide), have been studied in… Expand The mechanism of action of the lidocaine derivative transcainide was examined using [3H]batrachotoxinin 20 alpha-benzoate, which… Expand The working mechanism of Na+ channel block by a lidocaine analog, transcainide, was investigated. The Na+ channel block was… Expand Transcainidse is a new lidocaine analog that has been shown to suppress a range of cardiac arrhythmias in an initial clinical… Expand Transcainide was selected as an antiarrhythmic drug with potential clinical application. In isolated dog, sheep and rabbit… Expand