thymus development

The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric… (More)
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
The forkhead transcription factor Foxn1 is indispensable for thymus development, but the mechanisms by which it mediates thymic… (More)
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Review
2008
Review
2008
The epithelial architecture of the thymus fosters growth, differentiation, and T cell receptor repertoire selection of large… (More)
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Highly Cited
2008
Highly Cited
2008
Thymic T cell lineage commitment is dependent on Notch1 (N1) receptor-mediated signaling. Although the physiological ligands that… (More)
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2008
2008
The endodermal epithelial thymus anlage develops in tight association with neural crest (NC)-derived mesenchyme. This epithelial… (More)
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2005
2005
The thymus provides a specialised microenvironment for the development of T-cell precursors. This developmental programme depends… (More)
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1999
1999
During adult thymus development immature CD4(-)CD8(-) [double-negative (DN)] precursor cells pass through four phenotypically… (More)
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Highly Cited
1996
Highly Cited
1996
Pax1 is a transcriptional regulatory protein expressed during mouse embryogenesis and has been shown to have an important… (More)
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1995
1995
The mature TCR is composed of a clonotypic heterodimer (alpha beta or gamma delta) associated with the invariant CD3 components… (More)
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Highly Cited
1994
Highly Cited
1994
During T cell development in the thymus, T cell receptor (TCR) alpha, beta, gamma, and delta genes are rearranged and expressed… (More)
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1992
1992
We have monitored the expression of interleukin-7 (IL-7) in the developing embryonic mouse thymus by a combination of… (More)
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