thymidylate

 
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Pemetrexed represents the first antifolate cancer drug to be approved by the Food and Drug Administration in 20 years; it is… (More)
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Highly Cited
2008
Highly Cited
2008
Tetrahydrofolate (THF) polyglutamates are a family of cofactors that carry and chemically activate one-carbon units for… (More)
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Review
2008
Review
2008
The glycine cleavage system catalyzes the following reversible reaction: Glycine + H(4)folate + NAD(+) <==> 5,10-methylene-H(4… (More)
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Highly Cited
2006
Highly Cited
2006
F olate is a water soluble B vitamin, deficiency of which appears to play an important pathogenetic role in the development of… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE A 6 bp deletion polymorphism in the thymidylate synthase (TS) gene was investigated in order to determine its function… (More)
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Highly Cited
2002
Highly Cited
2002
Folate-dependent one-carbon metabolism is required for the synthesis of purines and thymidylate and for the remethylation of… (More)
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Highly Cited
1997
Highly Cited
1997
Folate is essential for the de novo biosynthesis of purines and thymidylate, and is an important mediator in the transfer of… (More)
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Highly Cited
1993
Highly Cited
1993
dUTP pyrophosphatase (dUTPase; EC 3.6.1.23) catalyses the hydrolysis of dUTP to dUMP and PPi and thereby prevents the… (More)
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Highly Cited
1986
Highly Cited
1986
The thymidine analog 3'-azido-3'-deoxythymidine (BW A509U, azidothymidine) can inhibit human immunodeficiency virus (HIV… (More)
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Highly Cited
1984
Highly Cited
1984
Aphidicolin, a specific inhibitor of DNA polymerase α, is known to induce chromosomal aberrations. At concentrations that did not… (More)
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