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thrombin aptamer

Known as: GGTTGGTGTGGTTGG, d(GGTTGGTGTGGTTGG), thrombin-binding aptamer 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Aptamers, Nucleotide

Narrower (1)

GS 522

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.
An acyclic pyrimidine analogue, containing a five-member cycle fused on the pyrimidine ring, was synthesized and introduced at… Expand
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2009
2009
Single-molecule detection of folding and unfolding of the G-quadruplex aptamer in a nanopore nanocavity
Guanine-rich nucleic acids can form G-quadruplexes that are important in gene regulation, biosensor design and nano-structure… Expand
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2006
2006
The thrombin binding aptamer GGTTGGTGTGGTTGG forms a bimolecular guanine tetraplex.
In the literature, the thrombin binding aptamer GGTTGGTGTGGTTGG is generally taken as a prototype of an intramolecular guanine… Expand
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1998
1998
Pharmacokinetics and Biodistribution of a Nucleotide-Based Thrombin Inhibitor in Rats
AbstractPurpose. To characterize the pharmacokinetic and tissue distribution profiles of a nucleotide-based thrombin inhibitor… Expand
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1998
1998
N2- and C8-substituted oligodeoxynucleotides with enhanced thrombin inhibitory activity in vitro and in vivo.
2'-Deoxyguanosine (G) analogues carrying various hydrophobic substituents in the N2 and C8 positions were synthesized and… Expand
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1998
1998
In vitro and in vivo activities of oligodeoxynucleotide-based thrombin inhibitors containing neutral formacetal linkages.
A series of 15-mer oligodeoxynucleotide analogues were synthesized, and their thrombin inhibitory activities in vitro and in vivo… Expand
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Highly Cited
1996
Highly Cited
1996
An ambiguous structure of a DNA 15-mer thrombin complex.
The structure of a complex between thrombin and a GGTTGGTGTGGTTGG DNA 15-mer has been analyzed crystallographically. The solution… Expand
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1995
1995
A Novel Oligodeoxynucleotide Inhibitor of Thrombin. II. Pharmacokinetics in the Cynomolgus Monkey
AbstractPurpose. To determine the pharmacokinetics of GS-522, an oligodeoxynucleotide (GGTTGGTGTGGTTGG) inhibitor of thrombin… Expand
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1994
1994
A novel nucleotide-based thrombin inhibitor inhibits clot-bound thrombin and reduces arterial platelet thrombus formation.
A novel thrombin inhibitor based on single-stranded (ss) deoxynucleotides with the sequence GGTTGGTGTGGTTGG (thrombin aptamer… Expand
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Highly Cited
1993
Highly Cited
1993
In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits.
Using a novel in vitro selection/amplification technique, we have recently identified a new class of thrombin inhibitors based on… Expand
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