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thrombin aptamer

Known as: GGTTGGTGTGGTTGG, d(GGTTGGTGTGGTTGG), thrombin-binding aptamer 
 
National Institutes of Health

Papers overview

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2012
2012
An acyclic pyrimidine analogue, containing a five-member cycle fused on the pyrimidine ring, was synthesized and introduced at… Expand
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2009
2009
Guanine-rich nucleic acids can form G-quadruplexes that are important in gene regulation, biosensor design and nano-structure… Expand
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2006
2006
In the literature, the thrombin binding aptamer GGTTGGTGTGGTTGG is generally taken as a prototype of an intramolecular guanine… Expand
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1998
1998
AbstractPurpose. To characterize the pharmacokinetic and tissue distribution profiles of a nucleotide-based thrombin inhibitor… Expand
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1998
1998
2'-Deoxyguanosine (G) analogues carrying various hydrophobic substituents in the N2 and C8 positions were synthesized and… Expand
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1998
1998
A series of 15-mer oligodeoxynucleotide analogues were synthesized, and their thrombin inhibitory activities in vitro and in vivo… Expand
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Highly Cited
1996
Highly Cited
1996
The structure of a complex between thrombin and a GGTTGGTGTGGTTGG DNA 15-mer has been analyzed crystallographically. The solution… Expand
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1995
1995
AbstractPurpose. To determine the pharmacokinetics of GS-522, an oligodeoxynucleotide (GGTTGGTGTGGTTGG) inhibitor of thrombin… Expand
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1994
1994
A novel thrombin inhibitor based on single-stranded (ss) deoxynucleotides with the sequence GGTTGGTGTGGTTGG (thrombin aptamer… Expand
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Highly Cited
1993
Highly Cited
1993
Using a novel in vitro selection/amplification technique, we have recently identified a new class of thrombin inhibitors based on… Expand
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