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thrombin aptamer
Known as:
GGTTGGTGTGGTTGG
, d(GGTTGGTGTGGTTGG)
, thrombin-binding aptamer
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Aptamers, Nucleotide
Narrower (1)
GS 522
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.
N. Borbone
,
M. Bucci
,
+12 authors
M. Scuotto
Journal of medicinal chemistry
2012
Corpus ID: 207230547
An acyclic pyrimidine analogue, containing a five-member cycle fused on the pyrimidine ring, was synthesized and introduced at…
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Highly Cited
2009
Highly Cited
2009
Single-molecule detection of folding and unfolding of the G-quadruplex aptamer in a nanopore nanocavity
Ji Wook Shim
,
Q. Tan
,
Li-Qun Gu
Nucleic acids research
2009
Corpus ID: 2732874
Guanine-rich nucleic acids can form G-quadruplexes that are important in gene regulation, biosensor design and nano-structure…
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2006
2006
The thrombin binding aptamer GGTTGGTGTGGTTGG forms a bimolecular guanine tetraplex.
M. Fialová
,
J. Kypr
,
M. Vorlíčková
Biochemical and biophysical research…
2006
Corpus ID: 33527806
In the literature, the thrombin binding aptamer GGTTGGTGTGGTTGG is generally taken as a prototype of an intramolecular guanine…
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2004
2004
Pharmacokinetics and Biodistribution of a Nucleotide-Based Thrombin Inhibitor in Rats
Larisa Reyderman
,
S. Stavchansky
Pharmaceutical Research
2004
Corpus ID: 3241594
AbstractPurpose. To characterize the pharmacokinetic and tissue distribution profiles of a nucleotide-based thrombin inhibitor…
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1998
1998
N2- and C8-substituted oligodeoxynucleotides with enhanced thrombin inhibitory activity in vitro and in vivo.
G. He
,
S. Krawczyk
,
+7 authors
N. Bischofberger
Journal of medicinal chemistry
1998
Corpus ID: 36590015
2'-Deoxyguanosine (G) analogues carrying various hydrophobic substituents in the N2 and C8 positions were synthesized and…
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1998
1998
In vitro and in vivo activities of oligodeoxynucleotide-based thrombin inhibitors containing neutral formacetal linkages.
G. He
,
J. Williams
,
+8 authors
N. Bischofberger
Journal of medicinal chemistry
1998
Corpus ID: 24944761
A series of 15-mer oligodeoxynucleotide analogues were synthesized, and their thrombin inhibitory activities in vitro and in vivo…
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Highly Cited
1996
Highly Cited
1996
An ambiguous structure of a DNA 15-mer thrombin complex.
K. Padmanabhan
,
A. Tulinsky
Acta crystallographica. Section D, Biological…
1996
Corpus ID: 23501312
The structure of a complex between thrombin and a GGTTGGTGTGGTTGG DNA 15-mer has been analyzed crystallographically. The solution…
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Highly Cited
1994
Highly Cited
1994
A novel nucleotide-based thrombin inhibitor inhibits clot-bound thrombin and reduces arterial platelet thrombus formation
W. Li
,
A. Kaplan
,
G. B. Grant
,
J. Toole
,
L. Leung
1994
Corpus ID: 209138437
A novel thrombin inhibitor based on single-stranded (ss) deoxynucleotides with the sequence GGTTGGTGTGGTTGG (thrombin aptamer…
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1994
1994
A novel nucleotide-based thrombin inhibitor inhibits clot-bound thrombin and reduces arterial platelet thrombus formation.
W. X. Li
,
A. Kaplan
,
G. Grant
,
J. Toole
,
L. Leung
Blood
1994
Corpus ID: 29862655
A novel thrombin inhibitor based on single-stranded (ss) deoxynucleotides with the sequence GGTTGGTGTGGTTGG (thrombin aptamer…
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Highly Cited
1993
Highly Cited
1993
In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits.
L. Griffin
,
G. Tidmarsh
,
L. C. Bock
,
J. Toole
,
L. Leung
Blood
1993
Corpus ID: 6491346
Using a novel in vitro selection/amplification technique, we have recently identified a new class of thrombin inhibitors based on…
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