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thiacremonone

 
National Institutes of Health

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Thiophenes

Papers overview

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2016
2016
Inhibitory effect of thiacremonone on MPTP-induced dopaminergic neurodegeneration through inhibition of p38 activation
Neuroinflammation is implicated for dopaminergic neurodegeneration. Sulfur compounds extracted from garlic have been shown to… Expand
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2015
2015
Thiacremonone Potentiates Anti-Oxidant Effects to Improve Memory Dysfunction in an APP/PS1 Transgenic Mice Model
Alzheimer’s disease (AD) is pathologically characterized by excessive accumulation of amyloid-beta (Aβ) peptide. Evidence… Expand
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2014
2014
Anti-Cancer Effect of Thiacremonone through Down Regulation of Peroxiredoxin 6
Thiacremonone (2, 4-dihydroxy-2, 5-dimethyl-thiophene-3-one) is an antioxidant substance as a novel sulfur compound generated… Expand
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2013
2013
Curative Effects of Thiacremonone against Acetaminophen-Induced Acute Hepatic Failure via Inhibition of Proinflammatory Cytokines Production and Infiltration of Cytotoxic Immune Cells and Kupffer…
High doses of acetaminophen (APAP; N-acetyl-p-aminophenol) cause severe hepatotoxicity after metabolic activation by cytochrome… Expand
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2012
2012
Antiobesity Effects of a Sulfur Compound Thiacremonone Mediated via Down‐regulation of Serum Triglyceride and Glucose Levels and Lipid Accumulation in the Liver of db/db Mice
Garlic is widely used as a spice. Garlic extracts exert anticancer and antiinflammatory effects, but its antiobesity efficacy… Expand
2012
2012
Thiacremonone, a sulfur compound isolated from garlic, attenuates lipid accumulation partially mediated via AMPK activation in 3T3-L1 adipocytes.
Garlic extracts exert anti-cancer and anti-inflammatory effects. However, the anti-adipogenic effect of garlic-derived compounds… Expand
2012
2012
Anti-amyloidogenic effect of thiacremonone through anti-inflamation in vitro and in vivo models.
Neuroinflammation is implicated for amyloidogenesis. Sulfur compounds extracted from garlic have been shown to have anti… Expand
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Highly Cited
2009
Highly Cited
2009
Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfurcompound isolated from garlic via inhibition of NF-κB
IntroductionSulfur compounds isolated from garlic exert anti-inflammatory properties. We recently isolated thiacremonone, a novel… Expand
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2009
2009
Thiacremonone Augments Chemotherapeutic Agent–Induced Growth Inhibition in Human Colon Cancer Cells through Inactivation of Nuclear Factor-κB
Chemotherapeutic strategies commonly use multiple agents to overcome drug resistance and to lower drug toxicity. Activation of… Expand
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Highly Cited
2007
Highly Cited
2007
Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells.
Compounds such as S-allylmercaptocysteine, diallyl disulfide, and S-trityl-L-cysteine isolated from garlic have been known to be… Expand
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