Skip to search formSkip to main contentSkip to account menu

tezosentan

Known as: 5-isopropyl-pyridine-2-sulfonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-1H-tetrazol-5-yl--pyridin-4-yl)--pyrimidin-4-ylamide, N-(6-(2-Hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-(1H-tetrazol-5-yl)-4-pyridyl)-4-pyrimidinyl)-5-isopropyl-2-pyridinesulfonamide, tezosentan [Chemical/Ingredient] 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

PyridinesTetrazolesVasodilator Agents

Narrower (2)

RO 61-0612Veletri

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Differential vasomotor effects of insulin on gastrocnemius and soleus feed arteries in the OLETF rat model: role of endothelin‐1
•  What is the central question of this study? This study investigated the influence of obesity on insulin‐induced vasomotor… 
Review
2005
Review
2005
Overview of randomized clinical trials in acute heart failure syndromes.
2004
2004
TEZOSENTAN COUNTERACTS ENDOTOXIN-INDUCED PULMONARY EDEMA AND IMPROVES GAS EXCHANGE
Sepsis-induced acute lung injury is still associated with high morbidity and mortality. The pathophysiology is complex, and… 
2004
2004
Usefulness of an elevated troponin-I in predicting clinical events in patients admitted with acute heart failure and acute coronary syndrome (from the RITZ-4 trial).
2002
2002
Entry-Into-Humans Study with Tezosentan, an Intravenous Dual Endothelin Receptor Antagonist
The purpose of this study was to investigate the tolerability, pharmacokinetics, and pharmacodynamics of ascending doses of… 
2002
2002
Effects of tezosentan, a dual endothelin receptor antagonist, on the cardiovascular and renal systems of neonatal piglets during endotoxic shock.
BACKGROUND/PURPOSE Endothelin is a potent mediator of the cardiovascular and renal systems. Studies have found that endothelin… 
Highly Cited
2001
Highly Cited
2001
THE USE OF THE ENDOTHELIN RECEPTOR ANTAGONIST, TEZOSENTAN, BEFORE OR AFTER RENAL ISCHEMIA PROTECTS RENAL FUNCTION1
Background. Utilization of organs subjected to ischemia/reperfusion (I/R) injury could expand the donor pool. Endothelin (ET) is… 
1992
1992
Blocking hypothalamic AT1 receptors lowers blood pressure in salt-sensitive rats.
Previous studies from our laboratory have shown that microinjection of DuP 753 (2-n-butyl-4-chloro-5-(hydroxymethyl)-1-[[2'-(1H… 
Highly Cited
1991
Highly Cited
1991
Effect of Angiotensin II Antagonism on Canine Renal Sympathetic Nerve Function
The objective of this study was to examine effects of nonpeptide angiotensin II (Ang II) receptor antagonists on renal… 
1985
1985
Thermographic evaluation of the hemodynamic effect of the antithrombotic drug cilostazol in peripheral arterial occlusion.
Cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC-13013) was evaluated experimentally… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)