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tezosentan

Known as: 5-isopropyl-pyridine-2-sulfonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-1H-tetrazol-5-yl--pyridin-4-yl)--pyrimidin-4-ylamide, N-(6-(2-Hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-(1H-tetrazol-5-yl)-4-pyridyl)-4-pyrimidinyl)-5-isopropyl-2-pyridinesulfonamide, tezosentan [Chemical/Ingredient] 
 
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
CONTEXT Plasma concentrations of the vasoconstrictor peptide endothelin-1 are increased in patients with heart failure, and… Expand
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Highly Cited
2007
Highly Cited
2007
The elimination process of the endothelin receptor antagonist bosentan (Tracleer) in humans is entirely dependent on metabolism… Expand
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Highly Cited
2005
Highly Cited
2005
This study shows that 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone (cilostazol) suppresses the… Expand
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Highly Cited
2003
Highly Cited
2003
OBJECTIVES We sought to determine the effect of tezosentan in patients with acute decompensated heart failure (HF) associated… Expand
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Highly Cited
2003
Highly Cited
2003
OBJECTIVES We sought to investigate the efficacy and safety of tezosentan, a dual endothelin receptor antagonist, in patients… Expand
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Highly Cited
2003
Highly Cited
2003
OBJECTIVES The objective of this study was to evaluate the addition of intravenous (IV) tezosentan to standard therapy for… Expand
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Highly Cited
2001
Highly Cited
2001
Background —Endothelin-1, a powerful mediator of vasoconstriction, is increased in patients with congestive heart failure and… Expand
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Highly Cited
1999
Highly Cited
1999
Tezosentan (Ro 61-0612) [5-isopropyl-pyridine-2-sulfonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-1H-tetrazol-5-yl… Expand
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Highly Cited
1997
Highly Cited
1997
The principal excitatory neurotransmitter in the vertebrate central nervous system, L-glutamate, acts on three classes of… Expand
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Review
1991
Review
1991
DuP 753, 2-n-butyl-4-chloro-5-hydroxymethyl-1-[2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl]imidazole, potassium salt, was… Expand
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