tezosentan

Known as: 5-isopropyl-pyridine-2-sulfonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-1H-tetrazol-5-yl--pyridin-4-yl)--pyrimidin-4-ylamide, N-(6-(2-Hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-(1H-tetrazol-5-yl)-4-pyridyl)-4-pyrimidinyl)-5-isopropyl-2-pyridinesulfonamide, tezosentan [Chemical/Ingredient] 
 
National Institutes of Health

Papers overview

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2009
2009
BACKGROUND Renal injury induced by aortic ischemia-reperfusion (IR) is an important factor in the development of postoperative… (More)
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Highly Cited
2007
Highly Cited
2007
CONTEXT Plasma concentrations of the vasoconstrictor peptide endothelin-1 are increased in patients with heart failure, and… (More)
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Highly Cited
2007
Highly Cited
2007
The elimination process of the endothelin receptor antagonist bosentan (Tracleer) in humans is entirely dependent on metabolism… (More)
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2007
2007
UNLABELLED Renal vasoconstriction is a key factor in the development of hepatorenal syndrome (HRS) and may be secondary to… (More)
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2004
2004
Sepsis-induced acute lung injury is still associated with high morbidity and mortality. The pathophysiology is complex, and… (More)
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2003
2003
OBJECTIVES We sought to determine the effect of tezosentan in patients with acute decompensated heart failure (HF) associated… (More)
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2003
2003
OBJECTIVES We sought to investigate the efficacy and safety of tezosentan, a dual endothelin receptor antagonist, in patients… (More)
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2001
2001
BACKGROUND Endothelin-1, a potent vasoconstrictor, is elevated in congestive heart failure and is postulated to play a major role… (More)
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Highly Cited
1999
Highly Cited
1999
Tezosentan (Ro 61-0612) [5-isopropyl-pyridine-2-sulfonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-1H-tetrazol-5-yl… (More)
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Highly Cited
1997
Highly Cited
1997
The principal excitatory neurotransmitter in the vertebrate central nervous system, L-glutamate, acts on three classes of… (More)
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