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Plasma concentrations of the vasoconstrictor peptide endothelin-1 are increased in patients with heart failure, and… Expand The elimination process of the endothelin receptor antagonist bosentan (Tracleer) in humans is entirely dependent on metabolism… Expand This study shows that 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone (cilostazol) suppresses the… Expand OBJECTIVES
We sought to determine the effect of tezosentan in patients with acute decompensated heart failure (HF) associated… Expand OBJECTIVES
We sought to investigate the efficacy and safety of tezosentan, a dual endothelin receptor antagonist, in patients… Expand OBJECTIVES
The objective of this study was to evaluate the addition of intravenous (IV) tezosentan to standard therapy for… Expand Background —Endothelin-1, a powerful mediator of vasoconstriction, is increased in patients with congestive heart failure and… Expand Tezosentan (Ro 61-0612) [5-isopropyl-pyridine-2-sulfonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-1H-tetrazol-5-yl… Expand The principal excitatory neurotransmitter in the vertebrate central nervous system, L-glutamate, acts on three classes of… Expand DuP 753, 2-n-butyl-4-chloro-5-hydroxymethyl-1-[2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl]imidazole, potassium salt, was… Expand