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tasisulam

Known as: N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide 
An acyl-sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis… 
National Institutes of Health

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LY 573636

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry.
Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling… 
2017
2017
Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam
Background and ObjectivesCytochrome P450 2C9 (CYP2C9) is involved in the biotransformation of many commonly used drugs, and… 
2017
2017
Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam
Cytochrome P450 2C9 (CYP2C9) is involved in the biotransformation of many commonly used drugs, and significant drug interactions… 
2016
2016
Synthesis of a Sulfonimidamide-Based Analog of Tasisulam and Its Biological Evaluation in the Melanoma Cell Lines SKMel23 and A375
Tasisulam is a promising antitumor agent with complex pharmacology, which is used as an antiproliferative agent in patients with… 
2015
2015
An innovative, multi-arm, complete phase 1b study of the novel anti-cancer agent tasisulam in patients with advanced solid tumors
SummaryBackground This phase Ib study used a parallel, multi-arm design to examine tasisulam-sodium (hereafter tasisulam), a drug… 
2013
2013
P06.06 EFFECTS OF TASISULAM SODIUM ON THE PHARMACOKINETICS OF TOLBUTAMIDE IN PATIENTS WITH ADVANCED SOLID TUMOURS
Background: Tasisulam sodium (tasisulam) is a novel anticancer agent that induces apoptosis and has shown activity in a wide… 
2013
2013
Tasisulam-sodium in combination with liposomal doxorubicin in patients with ovarian cancer.
5551 Background: Tasisulam-sodium (TASI) is a novel, highly albumin-bound small molecule that induces tumor cell apoptosis and… 
2012
2012
A rare case of primary rhabdoid melanoma of the urinary bladder treated with ipilimumab, an anti-CTLA 4 monoclonal antibody
Primary melanoma of the urinary bladder is a rare subentity of melanoma. The same applies for melanoma of the rhabdoid… 
2012
2012
Phase II results of tasisulam-sodium in previously treated patients with metastatic breast cancer.
114 Background: Tasisulam, a novel acylsulfonamide antineoplastic agent, promotes apoptosis, exhibits antiangiogenic activities… 
2010
2010
286 Tailored dosing of tasisulam-sodium (LY573636-sodium) to reduce hematologic toxicity and improve therapeutic index
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