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tasidotin

A third generation, synthetic, water-soluble, pentapeptide analog of the marine depsipeptide dolastatin 15, with potential antimitotic and… Expand
National Institutes of Health

Papers overview

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2019
2019
This work presents an account of the reactivity behavior of the anticancer marine drugs, Soblidotin and Tasidotin, based on the… Expand
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Review
2018
Review
2018
Microalgae are one of the oldest microorganisms, that grow in various hostile environments, ranging from deserts to Antarctica… Expand
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2013
2013
  • M. Lopus
  • Molecular and Cellular Biochemistry
  • 2013
  • Corpus ID: 12268937
Dolastatin 15 (DL15) is a potent, tubulin-targeted, vinca-site binding, anticancer agent that induces mitotic arrest and inhibit… Expand
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2009
2009
Tasidotin, an oncolytic drug in phase II clinical trials, is a peptide analog of the antimitotic depsipeptide dolastatin 15. In… Expand
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2009
2009
PurposeThe dynamic instability of microtubules in cells is one of the key targets of anticancer therapeutics. Microtubule… Expand
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2008
2008
PurposeTo evaluate the plasma and cerebrospinal fluid (CSF) pharmacokinetics and CSF penetration of tasidotin and metabolites in… Expand
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2007
2007
Tasidotin (ILX-651), an orally active synthetic microtubule-targeted derivative of the marine depsipeptide dolastatin-15, is… Expand
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2005
2005
Purpose: To determine the maximum tolerated dose, dose-limiting toxicity, and pharmacokinetics of the dolastatin-15 analogue… Expand
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2005
2005
Purpose: To determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and pharmacokinetics of tasidotin (ILX651… Expand
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Review
2005
Review
2005