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National Institutes of Health
analogs & derivatives
Semantic Scholar uses AI to extract papers important to this topic.
Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines.
Kyle A Totaro
Bioorganic & medicinal chemistry
Corpus ID: 33566883
Natural products that inhibit the proteasome have been fruitful starting points for the development of drug candidates. Those of…
Syringolin B-inspired proteasome inhibitor analogue TIR-203 exhibits enhanced biological activity in multiple myeloma and neuroblastoma
Tannya R. Ibarra-Rivera
Corpus ID: 19369768
Context: The bacterium Pseudomonas syringae pv. syringae (Pss) is a pathogen of many plant species and causes, for example, brown…
Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells.
Crystal R Archer
Corpus ID: 24782674
Syrbactins belong to a recently emergent class of bacterial natural product inhibitors that irreversibly inhibit the proteasome…
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