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stubomycin

Known as: Cyclopent(i)azacyclononadecine-7,17(8H,19H)-dione, 9,10,13,14,15,16,20,20a-octahydro-15,18-dihydroxy-19-methoxy-2-methyl-9-phenyl-, hitachimycin 
 
National Institutes of Health

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Polyenes

Papers overview

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2018
2018
Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies
Given that many antifungal medications are susceptible to evolved resistance, there is a need for novel drugs with unique… Expand
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2015
2015
Genome mining of the hitachimycin biosynthetic gene cluster: involvement of a phenylalanine-2,3-aminomutase in biosynthesis.
Hitachimycin is a macrolactam antibiotic with (S)-β-phenylalanine (β-Phe) at the starter position of its polyketide skeleton. To… Expand
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2004
2004
Streptomyces scabrisporus sp. nov.
The taxonomic position was determined for a soil actinomycete, isolate KM-4927(T), that produced the antibiotic hitachimycin. The… Expand
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1989
1989
Chemical modification of hitachimycin. II. Synthesis and antitumor activities of carbonate derivatives.
Several carbonate derivatives of hitachimycin have been synthesized and evaluated their activities including antibacterial… Expand
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1989
1989
Chemical modification of hitachimycin. III. Synthesis and antitumor activities of amino acyl derivatives.
Amino acyl derivatives of hitachimycin have been synthesized and evaluated their activities including antibacterial, cytocidal… Expand
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1988
1988
Chemical modification of hitachimycin. Synthesis, antibacterial, cytocidal and in vivo antitumor activities of hitachimycin derivatives.
Several acyl derivatives of hitachimycin have been synthesized and their activities, including antibacterial, cytocidal against… Expand
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1985
1985
Mechanism of action of antitumor antibiotic stubomycin.
 
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1983
1983
Studies on the biological activity of stubomycin.
Stubomycin showed direct cytotoxic activity on mammalian cells, yeast, and fungi, and rapid hemolytic activity on mouse… Expand
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1982
1982
Antitumor activity of a new antitumor antibiotic, stubomycin.
The antitumor activity of a new antibiotic, stubomycin, against various murine tumors was studied. Stubomycin showed antitumor… Expand
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1981
1981
A new antitumor antibiotic, stubomycin.
A new antibiotic, stubomycin, was isolated from the culture broth and mycelia of Streptomyces strain No. KG-2245. Stubomycin was… Expand
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