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Given that many antifungal medications are susceptible to evolved resistance, there is a need for novel drugs with unique… Expand Hitachimycin is a macrolactam antibiotic with (S)‐β‐phenylalanine (β‐Phe) at the starter position of its polyketide skeleton. To… Expand The taxonomic position was determined for a soil actinomycete, isolate KM-4927(T), that produced the antibiotic hitachimycin. The… Expand Several carbonate derivatives of hitachimycin have been synthesized and evaluated their activities including antibacterial… Expand Amino acyl derivatives of hitachimycin have been synthesized and evaluated their activities including antibacterial, cytocidal… Expand Stubomycin (a.k.a. hitachimycin) is a novel macrocyclic lactam antitumor agent. Herein we report the complete stereostructure of… Expand Several acyl derivatives of hitachimycin have been synthesized and their activities, including antibacterial, cytocidal against… Expand Stubomycin showed direct cytotoxic activity on mammalian cells, yeast, and fungi, and rapid hemolytic activity on mouse… Expand The antitumor activity of a new antibiotic, stubomycin, against various murine tumors was studied. Stubomycin showed antitumor… Expand A new antibiotic, stubomycin, was isolated from the culture broth and mycelia of Streptomyces strain No. KG-2245. Stubomycin was… Expand