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spectinabilin

 
National Institutes of Health

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Pyrones

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2017
2017
Rare Polyene-polyol Macrolides from Mangrove-derived Streptomyces sp. ZQ4BG
Bioactive natural products from mangrove-derived actinomycetes are important sources for discovery of drug lead compounds. In… Expand
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2016
2016
New cytotoxic spectinabilin derivative from ant-associated Streptomyces sp. 1H-GS5
Insects are the most abundant and diverse animal class on earth and they are associated with an amazing variety of microorganisms… Expand
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2016
2016
Hangtaimycin, a peptide secondary metabolite discovered from Streptomyces spectabilis CPCC 200148 by chemical screening
Hangtaimycin, a peptide secondary metabolite discovered from Streptomyces spectabilis CPCC 200148 by chemical screening 
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2015
2015
Freedom and constraint in engineered noncolinear polyketide assembly lines.
Many pharmacologically important natural products are assembled by modular type I polyketide synthases (PKS), which typically act… Expand
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2014
2014
Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line.
The unusual nitro-substituted polyketides aureothin, neoaureothin (spectinabilin), and luteoreticulin, which are produced by… Expand
Highly Cited
2013
Highly Cited
2013
Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold.
Natural products (secondary metabolites) are a rich source of compounds with important biological activities. Eliciting pathway… Expand
2010
2010
Cloning and heterologous expression of the spectinabilin biosynthetic gene cluster from Streptomyces spectabilis.
Spectinabilin is a rare nitrophenyl-substituted polyketide metabolite. Here we report the cloning and heterologous expression of… Expand
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2010
2010
Isolation and structure elucidation of a novel androgen antagonist, arabilin, produced by Streptomyces sp. MK756-CF1
In the course of screening for a new type of androgen receptor (AR) antagonist, we isolated a novel compound, arabilin, with two… Expand
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2005
2005
The total synthesis of spectinabilin and its biomimetic conversion to SNF4435C and SNF4435D.
[reaction: see text] A short synthesis of (+/-)-spectinabilin via a trans-selective Suzuki coupling and subsequent Negishi-type… Expand
Highly Cited
2002
Highly Cited
2002
Potent In Vitro Antimalarial Activity of Metacycloprodigiosin Isolated from Streptomycesspectabilis BCC 4785
ABSTRACT Bioassay-guided fractionation of the extract from the fermentation broth of Streptomycesspectabilis BCC 4785 led to the… Expand
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