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sonidegib

Known as: (1,1'-Biphenyl)-3-carboxamide, N-(6-((2R,6S)-2,6-dimethyl-4-morpholinyl)-3-pyridinyl)-2- methyl-4'-(trifluoromethoxy)-, rel-, ERISMODEGIB, N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridin-3-yl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide 
An orally bioavailable small-molecule smoothened (Smo) antagonist with potential antineoplastic activity. Sonidegib selectively binds to the hedgehog… 
National Institutes of Health

Related topics

Related topics

4 relations
NCIt Antineoplastic Agent Terminologysonidegib 200 MG Oral Capsule [Odomzo]

Broader (1)

Smoothened Antagonist LDE225

Narrower (1)

sonidegib phosphate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Sonidegib ▼ Odomzo® (Sun Pharmaceutical) en carcinoma basocelular
Sonidegib es un nuevo inhibidor de la ruta de senalizacion Hedgehog (Hh), capaz de unirse a la proteina transmembrana Smoothened… 
2018
2018
The use of vismodegib in the treatment of basal cell carcinoma based on case reports
Basal cell carcinoma (BCC) is the most common skin cancer, usually located on the skin of the face and neck. Locally advanced… 
Review
2018
Review
2018
Sonidegib for basal cell carcinoma.
2017
2017
Sonidegib gets a new label for recurring laBCC
Sun Pharmaceutical Industries announced in September the FDA has approved a new label for sonidegib (Odomzo, Novartis), an oral… 
2015
2015
Sonidegib Approved for Advanced Basal Cell Carcinoma
Oncologists now have a new tool for treating locally advanced basal cell carcinoma. On July 24, 2015, The US Food and Drug… 
2015
2015
Treatment with two diff erent doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma ( BOLT ) : a multicentre , randomised , double-blind phase 2 trial
Mohs Surgery Center, Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX, USA (M R Migden MD… 
2015
2015
Preparation method of Sonidegib
The invention discloses a preparation method of Sonidegib, LDE225. An industrial raw material, namely L-lactate, which is easy to… 
2015
2015
Sonidegib offers new option for basal cell cancer
A newly approved medication called sonidegib (Odomzo) gives physicians a second option in a class of medications designed to… 
2014
2014
Taking a BET on hedgehog
U.S. researchers show that BET bromodomain inhibition could open up a new therapeutic strategy for hedgehog-driven cancers that… 
2013
2013
A PHASE 3, MULTICENTER, OPEN-LABEL, RANDOMIZED, CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF ORAL SONIDEGIB (LDE225) VERSUS TEMOZOLOMIDE IN PATIENTS WITH HEDGEHOG PATHWAY-ACTIVATED RELAPSED…