...............................................................................................................................................................................3 INTRODUCTION .........................................................................................................................................................................4 INTERVENTION STUDIES............................................................................................................................................................5 Angiographic studies............................................................................................................................................................5 Dietary intervention studies .................................................................................................................................................5 Statin intervention studies....................................................................................................................................................6 GUIDELINES BASED ON LITERATURE DATA ...............................................................................................................................7 Secondary prevention...........................................................................................................................................................7 Primary prevention ..............................................................................................................................................................8 Cost-effectiveness.................................................................................................................................................................9 CONCLUSION ..........................................................................................................................................................................10 GUIDELINES AND COST........................................................................................................13 ABSTRACT ..............................................................................................................................................................................13.............................................................................................................................................................................13 INTRODUCTION .......................................................................................................................................................................13 THE BALANCE BETWEEN COSTS AND EFFECTS .......................................................................................................................13 WHO DECIDES? .......................................................................................................................................................................14 THE CONSENSUS GUIDELINE ..................................................................................................................................................15 LIMITATIONS OF COST-EFFECTIVENESS ANALYSES ................................................................................................................17 CONCLUSION ..........................................................................................................................................................................19 WORKING GROUP..................................................................................................................21 REFERENCES.........................................................................................................................22