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sinenxan A
National Institutes of Health
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2 relations
Broader (2)
Acetates
Diterpenes
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
A New 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) Derivative Overcomes Paclitaxel Resistance by Inhibiting MAPK Signaling and Increasing Paclitaxel Accumulation in Breast Cancer Cells
M. Mei
,
D. Xie
,
+5 authors
Xiaoguang Chen
PloS one
2014
Corpus ID: 10740683
Tumor resistance due to multiple mechanisms seriously hinders the efficacy of chemotherapy drugs such as paclitaxel. The most…
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2010
2010
Synthesis and structure-activity relationships of sinenxan A derivatives as multidrug resistance reversal agents.
Meng Huang
,
X. Zhao
,
M. Zhang
,
J. Gu
,
Xiaoguang Chen
,
Dali Yin
Bioorganic & medicinal chemistry letters
2010
Corpus ID: 33845319
Two types of sinenxan A derivatives with different side chains at C-5 were synthesized and evaluated for their in vitro multidrug…
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2009
2009
Syl611, a novel semisynthetic taxane derivative, reverses multidrug resistance by p-glycoprotein inhibition and facilitating inward transmembrane action
Yi Zhang
,
H. Li
,
+6 authors
X. Chen
Cancer Chemotherapy and Pharmacology
2009
Corpus ID: 23351068
PurposeTo investigate the reversal mechanisms of a novel semisynthetic taxane derivative, Syl611. Syl611 is a structurally…
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2004
2004
14-Deoxy-sinenxan A的13位碳烯丙氧化条件的研究
顾军
,
尹大力
2004
Corpus ID: 179992098
以生物合成的SinenxanA(SIA)为起始物,在合成1,7,9-trideoxytaxol的路线中,化合物1为关键中间体,研究了以多种不同氧化剂、在不同条件下[1,2],对14-deoxy-SIA的13…
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2003
2003
[Microbial transformation of sinenxan A, a rich constituent in callus cultures of Taxus].
Ji-xun Zhan
,
J. Zhong
,
+4 authors
D. Guo
Yao xue xue bao = Acta pharmaceutica Sinica
2003
Corpus ID: 39158498
AIM To study the microbial transformation of sinenxan A. METHODS Choose two strains of Fungi (Mucor spinosus AS 3.3450 and…
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2003
2003
Biotransformation of 14-Deacetoxy-13-oxo sinenxan A by Ginkgo Cell Cultures
JimGuiDAI
,
MengZhang
,
MinYe
,
Wei-huaZhu
,
JiYuGUO
,
XiaoTianLIANG
2003
Corpus ID: 82624926
14-Deacetoxy-13-oxo sinenxan A (1) was converted to 9α-hydroxy-13-oxo-2α, 5α, 10β-triacetoxy-4(20),11-taxadiene (2) and 10…
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2003
2003
[Synthesis and drug resistant reversal activities of taxane-like multi-drug resistant reversal agents].
M. Zhang
,
D. Yin
,
H. Liu
,
J. Guo
,
X. Liang
Yao xue xue bao = Acta pharmaceutica Sinica
2003
Corpus ID: 22675877
AIM To design and synthesize a series of new taxoids with a 5-O-sidechain, and to test the multi-drug resistant reversal activity…
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1998
1998
[Studies on structure modification and structure-activity relationship of new taxoids derived from sinenxan a].
G. Huang
,
J. Guo
,
X. Liang
Yao xue xue bao = Acta pharmaceutica Sinica
1998
Corpus ID: 10874893
In order to develop new taxol analogues with possible antitumor properties, sinenxan A (SIA), a new biosynthetic taxoid, was…
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