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sinenxan A

National Institutes of Health

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AcetatesDiterpenes

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2014
2014
A New 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) Derivative Overcomes Paclitaxel Resistance by Inhibiting MAPK Signaling and Increasing Paclitaxel Accumulation in Breast Cancer Cells
Tumor resistance due to multiple mechanisms seriously hinders the efficacy of chemotherapy drugs such as paclitaxel. The most… 
2010
2010
Synthesis and structure-activity relationships of sinenxan A derivatives as multidrug resistance reversal agents.
2004
2004
14-Deoxy-sinenxan A的13位碳烯丙氧化条件的研究
以生物合成的SinenxanA(SIA)为起始物,在合成1,7,9-trideoxytaxol的路线中,化合物1为关键中间体,研究了以多种不同氧化剂、在不同条件下[1,2],对14-deoxy-SIA的13… 
2003
2003
[Microbial transformation of sinenxan A, a rich constituent in callus cultures of Taxus].
AIM To study the microbial transformation of sinenxan A. METHODS Choose two strains of Fungi (Mucor spinosus AS 3.3450 and… 
2003
2003
Biotransformation of 14－Deacetoxy－13－oxo sinenxan A by Ginkgo Cell Cultures
14-Deacetoxy-13-oxo sinenxan A (1) was converted to 9α-hydroxy-13-oxo-2α, 5α, 10β-triacetoxy-4(20),11-taxadiene (2) and 10… 
1998
1998
[Studies on structure modification and structure-activity relationship of new taxoids derived from sinenxan a].
In order to develop new taxol analogues with possible antitumor properties, sinenxan A (SIA), a new biosynthetic taxoid, was… 
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