sinenxan A

Tumor resistance due to multiple mechanisms seriously hinders the efficacy of chemotherapy drugs such as paclitaxel. The most… Expand

Two types of sinenxan A derivatives with different side chains at C-5 were synthesized and evaluated for their in vitro multidrug… Expand

PurposeTo investigate the reversal mechanisms of a novel semisynthetic taxane derivative, Syl611. Syl611 is a structurally… Expand

以生物合成的SinenxanA(SIA)为起始物,在合成1,7,9-trideoxytaxol的路线中,化合物1为关键中间体,研究了以多种不同氧化剂、在不同条件下[1,2],对14-deoxy-SIA的13… Expand

AIM To study the microbial transformation of sinenxan A. METHODS Choose two strains of Fungi (Mucor spinosus AS 3.3450 and… Expand

14-Deacetoxy-13-oxo sinenxan A (1) was converted to 9α-hydroxy-13-oxo-2α, 5α, 10β-triacetoxy-4(20),11-taxadiene (2) and 10… Expand

AIM To design and synthesize a series of new taxoids with a 5-O-sidechain, and to test the multi-drug resistant reversal activity… Expand

In order to develop new taxol analogues with possible antitumor properties, sinenxan A (SIA), a new biosynthetic taxoid, was… Expand