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setmelanotide

 
National Institutes of Health

Papers overview

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Review
2019
Review
2019
The melanocortin-4 receptor (MC4R) - embedded in the leptin-melanocortin pathway - is activated by proopiomelanocortin (POMC… Expand
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2019
2019
Human melanocortin-4 receptor (hMC4R) mutations have been implicated as the cause for about 6-8% of all severe obesity cases… Expand
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2019
2019
To date, available treatment strategies for multiple sclerosis (MS) are ineffective in preventing or reversing progressive… Expand
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Review
2018
Review
2018
Purpose of ReviewObesity is a global health crisis with detrimental effects on all organ systems leading to worsening disease… Expand
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2018
2018
Genetic defects underlying the melanocortin-4 receptor (MC4R) signaling pathway lead to severe obesity. Three severely obese LEPR… Expand
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2018
2018
Context The hypothalamic melanocortin 4 receptor (MC4R) pathway serves a critical role in regulating body weight. Loss of… Expand
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2017
2017
OBJECTIVE Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce… Expand
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Highly Cited
2016
Highly Cited
2016
Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia… Expand
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2016
2016
BACKGROUND AND PURPOSE α- and β-melanocyte-stimulating hormones (MSH) are derived from pro-opiomelanocortin (POMC) and are the… Expand
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2016
2016
Pro-opiomelanocortin deficiency is a rare cause of severe intractable obesity. Two patients have experienced dramatic weight loss… Expand
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