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selisistat

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat
To study the antinociceptive effect of single and repeated doses of resveratrol in a bone cancer pain model, and whether this… 
Review
2015
Review
2015
Morbus Huntington
ZusammenfassungHintergrundDie Huntington-Erkrankung (Huntington’s disease, HD) ist eine progrediente neurodegenerative Erkrankung… 
2014
2014
N02 Safety And Tolerability Of Selisistat For The Treatment Of Huntington’s Disease: Results From A Randomised, Double-blind, Placebo-controlled Phase Ii Trial
Background Selisistat is a first-in-class SirT1 inhibitor shown to be safe and well tolerated in healthy volunteers and HD… 
2012
2012
Q01 SIRT 1 mediated modulation of circulating cytokines in huntington's disease- pharmacodynamics results from phase 1B study of selisistat—A SIRT 1 inhibitor
Background Evidence suggests simultaneous dysfunction of CNS and peripheral inflammatory pathways in Huntington's disease (HD). A… 
2012
2012
F04 Selisistat: potential pharmacodynamic readouts based on transcriptomics
Background Siena Biotech SpA is developing selisistat (SEN0014196) as a potentially disease-modifying therapy for HD. Selisistat… 
2012
2012
FROM BIOLOGY TO THE BEDSIDE-SIRTUINS AS TARGETS FOR DISEASE MODIFICATION IN HUNTINGTON'S DISEASE: SELISISTAT PRECLINICAL DATA AND PRELIMINARY PHASE I RESULTS
To date no disease modifying therapy has shown efficacy in Huntington's Disease (HD). The PADDINGTON (Pharmacodynamic Approaches… 
2012
2012
F02 Selisistat: soluble HTT protein levels as a potential pharmacodynamic readout
Background Siena Biotech SpA is developing selisistat (SEN0014196) as a potentially disease-modifying therapy for HD. Selsistat… 
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