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sabiporide

National Institutes of Health

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2 relations

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BIIB 722

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Guanidines

Papers overview

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2015
2015
Interaction of Sodium Bicarbonate and Na+/H+ Exchanger Inhibition in the Treatment of Acute Metabolic Acidosis in Pigs
Objective:Administration of NaHCO3 does not improve cellular function or reduce the mortality of acute lactic acidosis. This… 
2014
2014
Coadministration of a Na+-H+ exchange inhibitor and sodium bicarbonate for the treatment of asphyxia-induced cardiac arrest in piglets
Background:The present study tested the hypothesis that addition of an inhibitor of Na+/H+ exchanger (NHE1) to sodium bicarbonate… 
2013
2013
Sabiporide Improves Cardiovascular Function, Decreases the Inflammatory Response and Reduces Mortality in Acute Metabolic Acidosis in Pigs
Introduction Acute metabolic acidosis impairs cardiovascular function and increases the mortality of critically ill patients… 
2012
2012
Sabiporide Reduces Ischemia-Induced Arrhythmias and Myocardial Infarction and Attenuates ERK Phosphorylation and iNOS Induction in Rats
The aim of the present study was to investigate the effects of sabiporide, a potent and selective NHE1 inhibitor, on myocardial… 
2010
2010
The effect of Na+/H+ exchanger-1 inhibition by sabiporide on blood–brain barrier dysfunction after ischemia/hypoxia in vivo and in vitro
2006
2006
Inhibition of Na+/H+‐exchanger with sabiporide attenuates the downregulation and uncoupling of the myocardial β‐adrenoceptor system in failing rabbit hearts
1 Chronic heart failure (HF) is characterized by left ventricular (LV) structural remodeling, impaired function, increased… 
2005
2005
Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia
2003
2003
Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects.
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