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rostafuroxin

Known as: 17-(3-furyl)-5beta-androstane-3,14,17-triol 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Androstanols

Narrower (1)

PST 2238

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Endogenous Ouabain and Related Genes in the Translation from Hypertension to Renal Diseases
The endogenous ouabain (EO) is a steroid hormone secreted by the adrenal gland with cardio-tonic effects. In this article, we… 
2018
2018
ROSTAFUROXIN AMELIORATES THE INWARD REMODELING AND STIFFNESS IN RESISTANCE ARTERIES FROM DEOXYCORTICOSTERONE ACETATE-SALT HYPERTENSIVE RATS
Objective: We have shown that rostafuroxin (ROSTA), an antagonist of endogenous ouabain (OUA), block the biding of OUA to Na+ K… 
2016
2016
Ouabain Contributes to Kidney Damage in a Rat Model of Renal Ischemia-Reperfusion Injury
Warm renal ischemia performed during partial nephrectomy has been found to be associated with kidney disease. Since endogenous… 
2014
2014
Rostafuroxin Protects from Podocyte Injury and Proteinuria Induced by Adducin Genetic Variants and Ouabain
Glomerulopathies are important causes of morbidity and mortality. Selective therapies that address the underlying mechanisms are… 
2012
2012
DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase.
BACKGROUND We have shown that the ouabain-sensitive α2 Na,K-ATPase is required for adrenocorticotropic hormone (ACTH)-induced… 
Review
2010
Review
2010
Genetics of primary hypertension: the clinical impact of adducin polymorphisms.
2010
2010
FOUR HUMAN GENE VARIANTS PREDICT THE ANTIHYPERTENSIVE ACTIVITY OF ROSTAFUROXIN, A SELECTIVE INHIBITOR OF THEIR EFFECTS ON THE NA, K PUMP: PP.21.316
Background: The genetic complexity of arterial hypertension hampers the approaches aimed at establishing the clinical impact of… 
2007
2007
Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.
Review
2006
Review
2006
Ouabain-dependent signaling in caveolae as a novel therapeutic target for hypertension.
Experimental and clinical evidence indicates that Endogenous Ouabain (EO) and Adducin polymorphism play a pathogenetic role in… 
2004
2004
Ouabain and Adducin for Specific Intervention on Sodium in HyperTension ( OASIS-HT ) : design of a pharmacogenomic dose-finding study
1Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular… 
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