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rostafuroxin

Known as: 17-(3-furyl)-5beta-androstane-3,14,17-triol 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Androstanols

Narrower (1)

PST 2238

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Ouabain–digoxin antagonism in rat arteries and neurones
‘Classic’ cardiotonic steroids (CTSs) all inhibit Na+,K+‐ATPase (Na+ pumps) and exert cardiotonic and vasotonic effects… 
Review
2012
Review
2012
Systemic Hypertension: The Roles of Salt, Vascular Na+/K+ ATPase and the Endogenous Glycosides, Ouabain and Marinobufagenin
Essential hypertension has been shown to be significantly associated with an increased risk for cardiovascular disease and is not… 
Highly Cited
2011
Highly Cited
2011
Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump
Bipolar disorder is a debilitating psychopathology with unknown etiology. Accumulating evidence suggests the possible involvement… 
2011
2011
Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin
BackgroundThe Ouabain and Adducin for Specific Intervention on Sodium in Hypertension (OASIS-HT) Trial was a phase-2 dose-finding… 
Highly Cited
2010
Highly Cited
2010
Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 2: Clinical Studies
Five genetic variants that affect Na,K-ATPase interactions predict the blood pressure response to rostafuroxin but not to… 
2010
2010
Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 1: Experimental Studies
Rostafuroxin lowers blood pressure in rats and disrupts mutant α-adducin and ouabain–Na,K-ATPase complex interaction with the Src… 
Review
2010
Review
2010
Genetics of primary hypertension: the clinical impact of adducin polymorphisms.
2007
2007
Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.
Review
2007
Review
2007
Endogenous and Exogenous Cardiac Glycosides and their Mechanisms of Action
Cardiac glycosides have been used for decades to treat congestive heart failure. The recent identification of cardiotonic… 
Review
2006
Review
2006
Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.
The genetic and environmental heterogeneity of essential hypertension is responsible for the individual variability of… 
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