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rostafuroxin

Known as: 17-(3-furyl)-5beta-androstane-3,14,17-triol 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Androstanols

Narrower (1)

PST 2238

Papers overview

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2014
2014
Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain.
Glomerulopathies are important causes of morbidity and mortality. Selective therapies that address the underlying mechanisms are… Expand
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2014
2014
Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+K+-ATPase/ cSRC pathway.
AIMS Endogenous ouabain is elevated in patients and experimental models of hypertension and is associated with elevated mortality… Expand
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2014
2014
Ouabain-digoxin antagonism in rat arteries and neurones.
'Classic' cardiotonic steroids (CTSs) such as digoxin and ouabain selectively inhibit Na+, K+ -ATPase (the Na+ pump) and, via Na… Expand
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Highly Cited
2011
Highly Cited
2011
Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump.
Bipolar disorder is a debilitating psychopathology with unknown etiology. Accumulating evidence suggests the possible involvement… Expand
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2011
2011
Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin
BackgroundThe Ouabain and Adducin for Specific Intervention on Sodium in Hypertension (OASIS-HT) Trial was a phase-2 dose-finding… Expand
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2010
2010
Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies.
Twenty years of genetic studies have not contributed to improvement in the clinical management of primary arterial hypertension… Expand
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2010
2010
Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 1: experimental studies.
Essential hypertension is a complex, multifactorial disease associated with a high cardiovascular risk and whose genetic… Expand
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Review
2010
Review
2010
Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.
An innovative approach to the therapy of essential hypertension (EH) and the related complications has been pursued by our group… Expand
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Review
2007
Review
2007
Endogenous and Exogenous Cardiac Glycosides and their Mechanisms of Action
Cardiac glycosides have been used for decades to treat congestive heart failure. The recent identification of cardiotonic… Expand
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Review
2006
Review
2006
Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.
The genetic and environmental heterogeneity of essential hypertension is responsible for the individual variability of… Expand
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