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ribose-phosphate pyrophosphokinase activity
Known as:
ribose phosphate diphosphokinase activity
, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity
, phosphoribosyl pyrophosphate synthetase activity
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Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). [EC:2.7.6.1, RHEA:15612]
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1995
1995
Tricistronic operon expression of the genes gcaD (tms), which encodes N-acetylglucosamine 1-phosphate uridyltransferase, prs, which encodes phosphoribosyl diphosphate synthetase, and ctc in…
I. Hilden
,
B. Krath
,
B. Hove-Jensen
Journal of bacteriology
1995
Corpus ID: 41535605
The gcaD, prs, and ctc genes were shown to be organized as a tricistronic operon. The transcription of the prs gene, measured as…
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1992
1992
dnaR function of the prs gene of Escherichia coli in initiation of chromosome replication.
Y. Sakakibara
Journal of molecular biology
1992
Corpus ID: 21222786
Highly Cited
1989
Highly Cited
1989
Phosphoribosylpyrophosphate (PRPP)‐less mutants of Escherichia coli
B. Hove-Jensen
Molecular microbiology
1989
Corpus ID: 551585
A DNA fragment encoding kanamycin resistance was inserted in vitro into a plasmid‐borne prs gene encoding…
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1981
1981
A gouty family with increased phosphoribosylpyrophosphate synthetase activity: case reports, familial studies, and kinetic studies of the abnormal enzyme.
I. Akaoka
,
S. Fujimori
,
+5 authors
Y. Horiuchi
The Journal of rheumatology
1981
Corpus ID: 22075673
Two male patients with urate overexcretion and clinical gout in a family showed activity of phosphoribosylpyrophosphate (PRPP…
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1977
1977
Regulation of Salmonella phosphoribosylpyrophosphate synthetase activity in vivo. Deductions from pool measurements.
W. C. Sadler
,
R. Switzer
The Journal of biological chemistry
1977
Corpus ID: 32973926
1976
1976
Phosphoribosylpyrophosphate synthetase is elevated in fibroblasts from patients with the Lesch-Nyhan syndrome.
D. Martin
,
B. Maler
Science
1976
Corpus ID: 130352
In subconfluent cultures of fibroblasts from patients with complete or partial deficiencies of hypoxanthine-guanine…
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1975
1975
Phosphoribosylpyrophosphate overproduction, a new metabolic abnormality in the Lesch Nyhan syndrome
G. H. Reem
Science
1975
Corpus ID: 638122
The activity of phosphoribosylpyrophosphate synthetase and the rate of phosphoribosylpyrophosphate accumulation are significantly…
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Highly Cited
1973
Highly Cited
1973
Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity
M. Becker
,
L. Meyer
,
A. Wood
,
J. Seegmiller
Science
1973
Corpus ID: 83796814
In hemolyzates from red cells of two brothers with purine overproduction and gout, activity of phosphoribosylpyrophosphate…
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Highly Cited
1973
Highly Cited
1973
Gout with purine overproduction due to increased phosphoribosylpyrophosphate synthetase activity.
M. Becker
,
L. Meyer
,
J. Seegmiller
The American journal of medicine
1973
Corpus ID: 19739719
Highly Cited
1973
Highly Cited
1973
Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in a family with gout and excessive purine synthesis.
M. Becker
,
P. Kostel
,
L. Meyer
,
J. Seegmiller
Proceedings of the National Academy of Sciences…
1973
Corpus ID: 2451985
Among affected members of a family (B. family) with excessive purine production and gout, activity of phosphoribosylpyrophosphate…
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