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ribose-phosphate pyrophosphokinase activity

Known as: ribose phosphate diphosphokinase activity, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity, phosphoribosyl pyrophosphate synthetase activity 
Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). [EC:2.7.6.1, RHEA:15612]
National Institutes of Health

Papers overview

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1995
1995
Tricistronic operon expression of the genes gcaD (tms), which encodes N-acetylglucosamine 1-phosphate uridyltransferase, prs, which encodes phosphoribosyl diphosphate synthetase, and ctc in…
The gcaD, prs, and ctc genes were shown to be organized as a tricistronic operon. The transcription of the prs gene, measured as… 
1992
1992
dnaR function of the prs gene of Escherichia coli in initiation of chromosome replication.
Highly Cited
1989
Highly Cited
1989
Phosphoribosylpyrophosphate (PRPP)‐less mutants of Escherichia coli
A DNA fragment encoding kanamycin resistance was inserted in vitro into a plasmid‐borne prs gene encoding… 
1981
1981
A gouty family with increased phosphoribosylpyrophosphate synthetase activity: case reports, familial studies, and kinetic studies of the abnormal enzyme.
Two male patients with urate overexcretion and clinical gout in a family showed activity of phosphoribosylpyrophosphate (PRPP… 
1977
1977
Regulation of Salmonella phosphoribosylpyrophosphate synthetase activity in vivo. Deductions from pool measurements.
1976
1976
Phosphoribosylpyrophosphate synthetase is elevated in fibroblasts from patients with the Lesch-Nyhan syndrome.
In subconfluent cultures of fibroblasts from patients with complete or partial deficiencies of hypoxanthine-guanine… 
1975
1975
Phosphoribosylpyrophosphate overproduction, a new metabolic abnormality in the Lesch Nyhan syndrome
The activity of phosphoribosylpyrophosphate synthetase and the rate of phosphoribosylpyrophosphate accumulation are significantly… 
Highly Cited
1973
Highly Cited
1973
Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity
In hemolyzates from red cells of two brothers with purine overproduction and gout, activity of phosphoribosylpyrophosphate… 
Highly Cited
1973
Highly Cited
1973
Gout with purine overproduction due to increased phosphoribosylpyrophosphate synthetase activity.
Highly Cited
1973
Highly Cited
1973
Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in a family with gout and excessive purine synthesis.
Among affected members of a family (B. family) with excessive purine production and gout, activity of phosphoribosylpyrophosphate… 
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