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ribose-phosphate pyrophosphokinase activity
Known as:
ribose phosphate diphosphokinase activity
, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity
, phosphoribosyl pyrophosphate synthetase activity
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Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). [EC:2.7.6.1, RHEA:15612]
National Institutes of Health
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1989
1989
Decreased erythrocyte phosphoribosylpyrophosphate synthetase activity and impaired formation in thalassemia minor: a mechanism for decreased adenine nucleotide content.
C. R. Zerez
,
N. Lachant
,
K. Tanaka
Journal of Laboratory and Clinical Medicine
1989
Corpus ID: 40551375
Adenosine triphosphate (ATP) and adenosine diphosphate levels are decreased in erythrocytes from individuals with beta…
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1982
1982
Studies of the kinetic mechanism of hypoxanthine-guanine phosphoribosyltransferase from yeast.
L. Z. Ali
,
D. Sloan
Journal of Biological Chemistry
1982
Corpus ID: 13069905
1982
1982
Mutant strains of Salmonella typhimurium with defective phosphoribosylpyrophosphate synthetase activity.
N. K. Pandey
,
R. Switzer
Journal of General Microbiology
1982
Corpus ID: 22045199
A mutant of Salmonella typhimurium with undetectable phosphoribosylpyrophosphate (PRPP) synthetase activity in vitro and…
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1981
1981
A gouty family with increased phosphoribosylpyrophosphate synthetase activity: case reports, familial studies, and kinetic studies of the abnormal enzyme.
I. Akaoka
,
S. Fujimori
,
+5 authors
Y. Horiuchi
Journal of Rheumatology
1981
Corpus ID: 22075673
Two male patients with urate overexcretion and clinical gout in a family showed activity of phosphoribosylpyrophosphate (PRPP…
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1979
1979
Increased phosphoribosylpyrophosphate synthetase activity in fibroblasts of hypoxanthine-guanine phosphoribosyl transferase deficient patients.
B. M. Torrelio
,
M. Paz
Biochemical and Biophysical Research…
1979
Corpus ID: 39077699
1977
1977
Regulation of Salmonella phosphoribosylpyrophosphate synthetase activity in vivo. Deductions from pool measurements.
W. C. Sadler
,
R. Switzer
Journal of Biological Chemistry
1977
Corpus ID: 32973926
1976
1976
Phosphoribosylpyrophosphate synthetase is elevated in fibroblasts from patients with the Lesch-Nyhan syndrome.
D. Martin
,
B. Maler
Science
1976
Corpus ID: 130352
In subconfluent cultures of fibroblasts from patients with complete or partial deficiencies of hypoxanthine-guanine…
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1976
1976
Purine and phosphoribosylpyrophosphate synthesis in differentiating murine virus‐induced erythroleukemic cells in vitro
G. H. Reem
,
C. Friend
Journal of Cellular Physiology
1976
Corpus ID: 28919032
Phosphoribosylpyrophosphate synthetase activity was determined in Friend virus‐inducted erythroleukemic cells in culture…
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1975
1975
Phosphoribosylpyrophosphate overproduction, a new metabolic abnormality in the Lesch Nyhan syndrome
G. H. Reem
Science
1975
Corpus ID: 638122
The activity of phosphoribosylpyrophosphate synthetase and the rate of phosphoribosylpyrophosphate accumulation are significantly…
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Highly Cited
1973
Highly Cited
1973
Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in a family with gout and excessive purine synthesis.
M. Becker
,
P. Kostel
,
L. Meyer
,
J. Seegmiller
Proceedings of the National Academy of Sciences…
1973
Corpus ID: 2451985
Among affected members of a family (B. family) with excessive purine production and gout, activity of phosphoribosylpyrophosphate…
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