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ribose-phosphate pyrophosphokinase activity

Known as: ribose phosphate diphosphokinase activity, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity, phosphoribosyl pyrophosphate synthetase activity 
Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). [EC:2.7.6.1, RHEA:15612]
National Institutes of Health

Papers overview

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1989
1989
Decreased erythrocyte phosphoribosylpyrophosphate synthetase activity and impaired formation in thalassemia minor: a mechanism for decreased adenine nucleotide content.
Adenosine triphosphate (ATP) and adenosine diphosphate levels are decreased in erythrocytes from individuals with beta… 
1982
1982
Studies of the kinetic mechanism of hypoxanthine-guanine phosphoribosyltransferase from yeast.
1982
1982
Mutant strains of Salmonella typhimurium with defective phosphoribosylpyrophosphate synthetase activity.
A mutant of Salmonella typhimurium with undetectable phosphoribosylpyrophosphate (PRPP) synthetase activity in vitro and… 
1981
1981
A gouty family with increased phosphoribosylpyrophosphate synthetase activity: case reports, familial studies, and kinetic studies of the abnormal enzyme.
Two male patients with urate overexcretion and clinical gout in a family showed activity of phosphoribosylpyrophosphate (PRPP… 
1979
1979
Increased phosphoribosylpyrophosphate synthetase activity in fibroblasts of hypoxanthine-guanine phosphoribosyl transferase deficient patients.
1977
1977
Regulation of Salmonella phosphoribosylpyrophosphate synthetase activity in vivo. Deductions from pool measurements.
1976
1976
Phosphoribosylpyrophosphate synthetase is elevated in fibroblasts from patients with the Lesch-Nyhan syndrome.
In subconfluent cultures of fibroblasts from patients with complete or partial deficiencies of hypoxanthine-guanine… 
1976
1976
Purine and phosphoribosylpyrophosphate synthesis in differentiating murine virus‐induced erythroleukemic cells in vitro
Phosphoribosylpyrophosphate synthetase activity was determined in Friend virus‐inducted erythroleukemic cells in culture… 
1975
1975
Phosphoribosylpyrophosphate overproduction, a new metabolic abnormality in the Lesch Nyhan syndrome
The activity of phosphoribosylpyrophosphate synthetase and the rate of phosphoribosylpyrophosphate accumulation are significantly… 
Highly Cited
1973
Highly Cited
1973
Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in a family with gout and excessive purine synthesis.
Among affected members of a family (B. family) with excessive purine production and gout, activity of phosphoribosylpyrophosphate… 
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