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ribose-phosphate pyrophosphokinase activity

Known as: ribose phosphate diphosphokinase activity, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity, phosphoribosyl pyrophosphate synthetase activity 
Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). [EC:2.7.6.1, RHEA:15612]
National Institutes of Health

Papers overview

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1995
1995
Tricistronic operon expression of the genes gcaD (tms), which encodes N-acetylglucosamine 1-phosphate uridyltransferase, prs, which encodes phosphoribosyl diphosphate synthetase, and ctc in…
The gcaD, prs, and ctc genes were shown to be organized as a tricistronic operon. The transcription of the prs gene, measured as… Expand
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1994
1994
A simplified method for the determination of phosphoribosylpyrophosphate synthetase activity in hemolysates.
Methods currently employed for measurement of phosphoribosylpyrophosphate synthetase (ribophosphate pyrophosphokinase; PRPPs… Expand
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1989
1989
Phosphoribosylpyrophosphate (PRPP)-less mutants of Escherichia coli.
A DNA fragment encoding kanamycin resistance was inserted in vitro into a plasmid-borne prs gene encoding… Expand
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1989
1989
Decreased erythrocyte phosphoribosylpyrophosphate synthetase activity and impaired formation in thalassemia minor: a mechanism for decreased adenine nucleotide content.
Adenosine triphosphate (ATP) and adenosine diphosphate levels are decreased in erythrocytes from individuals with beta… Expand
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1982
1982
Mutant strains of Salmonella typhimurium with defective phosphoribosylpyrophosphate synthetase activity.
A mutant of Salmonella typhimurium with undetectable phosphoribosylpyrophosphate (PRPP) synthetase activity in vitro and… Expand
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1981
1981
A gouty family with increased phosphoribosylpyrophosphate synthetase activity: case reports, familial studies, and kinetic studies of the abnormal enzyme.
Two male patients with urate overexcretion and clinical gout in a family showed activity of phosphoribosylpyrophosphate (PRPP… Expand
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1975
1975
Phosphoribosylpyrophosphate overproduction, a new metabolic abnormality in the Lesch Nyhan syndrome
The activity of phosphoribosylpyrophosphate synthetase and the rate of phosphoribosylpyrophosphate accumulation are significantly… Expand
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1973
1973
Gout with purine overproduction due to increased phosphoribosylpyrophosphate synthetase activity.
Abstract Two brothers with marked purine overproduction and clinical gout showed activity of the enzyme… Expand
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1973
1973
Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity
In hemolyzates from red cells of two brothers with purine overproduction and gout, activity of phosphoribosylpyrophosphate… Expand
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1973
1973
Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in a family with gout and excessive purine synthesis.
Among affected members of a family (B. family) with excessive purine production and gout, activity of phosphoribosylpyrophosphate… Expand
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