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ribose-phosphate pyrophosphokinase activity

Known as: ribose phosphate diphosphokinase activity, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity, phosphoribosyl pyrophosphate synthetase activity 
Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). [EC:2.7.6.1, RHEA:15612]
National Institutes of Health

Papers overview

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1992
1992
dnaR function of the prs gene of Escherichia coli in initiation of chromosome replication.
A new Escherichia coli mutant named dnaR, which was temperature sensitive in initiation of DNA replication, has been… Expand
Highly Cited
1989
Highly Cited
1989
Phosphoribosylpyrophosphate (PRPP)‐less mutants of Escherichia coli
A DNA fragment encoding kanamycin resistance was inserted in vitro into a plasmid‐borne prs gene encoding… Expand
1982
1982
Studies of the kinetic mechanism of hypoxanthine-guanine phosphoribosyltransferase from yeast.
An assay procedure, utilizing high pressure liquid chromatography, has been designed which allows both reactions catalyzed by… Expand
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1981
1981
A gouty family with increased phosphoribosylpyrophosphate synthetase activity: case reports, familial studies, and kinetic studies of the abnormal enzyme.
Two male patients with urate overexcretion and clinical gout in a family showed activity of phosphoribosylpyrophosphate (PRPP… Expand
1977
1977
Regulation of Salmonella phosphoribosylpyrophosphate synthetase activity in vivo. Deductions from pool measurements.
 
1976
1976
Phosphoribosylpyrophosphate synthetase is elevated in fibroblasts from patients with the Lesch-Nyhan syndrome.
In subconfluent cultures of fibroblasts from patients with complete or partial deficiencies of hypoxanthine-guanine… Expand
1975
1975
Phosphoribosylpyrophosphate overproduction, a new metabolic abnormality in the Lesch Nyhan syndrome
The activity of phosphoribosylpyrophosphate synthetase and the rate of phosphoribosylpyrophosphate accumulation are significantly… Expand
Highly Cited
1973
Highly Cited
1973
Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity
In hemolyzates from red cells of two brothers with purine overproduction and gout, activity of phosphoribosylpyrophosphate… Expand
Highly Cited
1973
Highly Cited
1973
Gout with purine overproduction due to increased phosphoribosylpyrophosphate synthetase activity.
Abstract Two brothers with marked purine overproduction and clinical gout showed activity of the enzyme… Expand
Highly Cited
1973
Highly Cited
1973
Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in a family with gout and excessive purine synthesis.
Among affected members of a family (B. family) with excessive purine production and gout, activity of phosphoribosylpyrophosphate… Expand
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