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ribavirin amidine

Known as: TARIBAVIRIN, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine, viramidine 
An orally available prodrug of ribavirin, a synthetic nucleoside analog of ribofuranose with activity against a wide range of viruses, especially the… 
National Institutes of Health

Related topics

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3 relations

Broader (1)

Ribavirin
Taribavirin Hydrochlorideanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
A phase III study of the safety and efficacy of viramidine versus ribavirin in treatment‐naïve patients with chronic hepatitis C: ViSER1 results
Pegylated interferon (peg‐IFN) and ribavirin (RBV) are effective in eradicating the hepatitis C virus in more than half of… 
Highly Cited
2007
Highly Cited
2007
Virological response and safety outcomes in therapy-nai ve patients treated for chronic hepatitis C with taribavirin or ribavirin in combination with pegylated interferon alfa-2a: a randomized, phase…
Review
2006
Review
2006
Treating HCV with ribavirin analogues and ribavirin-like molecules.
Nucleos(t)ide analogues have proven useful in the treatment of viral infections. Ribavirin is a nucleoside, guanosine analogue… 
Highly Cited
2005
Highly Cited
2005
In vitro and in vivo influenza virus-inhibitory effects of viramidine.
2005
2005
Phosphorylation of Ribavirin and Viramidine by Adenosine Kinase and Cytosolic 5′-Nucleotidase II: Implications for Ribavirin Metabolism in Erythrocytes
ABSTRACT Many nucleoside analog drugs, such as ribavirin and viramidine, are activated or metabolized in vivo through 5… 
Highly Cited
2003
Highly Cited
2003
Activation and Deactivation of a Broad-Spectrum Antiviral Drug by a Single Enzyme: Adenosine Deaminase Catalyzes Two Consecutive Deamination Reactions
ABSTRACT Ribavirin is an approved broad-spectrum antiviral drug. A liver-targeting prodrug of ribavirin, viramidine, is in… 
Review
2003
Review
2003
Ribavirin, viramidine and adenosine-deaminase-catalysed drug activation: implication for nucleoside prodrug design
The epidemics caused by pathogenic viruses, such as HIV, hepatitis C virus (HCV) and most recently the severe acute respiratory… 
Highly Cited
2003
Highly Cited
2003
Viramidine, a Prodrug of Ribavirin, Shows Better Liver-Targeting Properties and Safety Profiles Than Ribavirin in Animals
Ribavirin, part of the current first line combination therapy for the treatment of chronic hepatitis C, may cause haemolytic… 
Review
2002
Review
2002
Prospects for hepatitis C virus therapeutics: levovirin and viramidine as improved derivatives of ribavirin.
Ribavirin, in combination with interferons, has proved clinically useful for the treatment of hepatitis C virus (HCV) infection… 
1988
1988
Effects of ribamidine, a 3-carboxamidine derivative of ribavirin, on experimentally induced Phlebovirus infections.
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