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ribavirin amidine

Known as: TARIBAVIRIN, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine, viramidine 
An orally available prodrug of ribavirin, a synthetic nucleoside analog of ribofuranose with activity against a wide range of viruses, especially the… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Ribavirin
Taribavirin Hydrochlorideanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
[10] THE SAFETY AND EFFICACY OF TARIBAVIRIN PLUS PEGYLATED INTERFERON ALFA-2a VERSUS RIBAVIRIN PLUS PEGYLATED INTERFERON ALFA-2a IN THERAPY-NAIVE PATIENTS INFECTED WITH HCV: PHASE 3 RESULTS
2005
2005
Ascending Multiple‐Dose Pharmacokinetics of Viramidine, a Prodrug of Ribavirin, in Adult Subjects With Compensated Hepatitis C Infection
The current study was carried out to evaluate pharmacokinetic profiles of viramidine and ribavirin in patients (n = 8 per dose… 
2004
2004
Dual-Action Mechanism of Viramidine Functioning as a Prodrug and as a Catabolic Inhibitor for Ribavirin
ABSTRACT An investigational nucleoside analogue drug, viramidine, has recently emerged as a potentially safer alternative to… 
2004
2004
Treatment of Mannan-Enhanced Influenza B Virus Infections in Mice with Oseltamivir, Ribavirin and Viramidine
Mannan, a polysaccharide preparation from Saccharomyces cerevisiae, has previously been shown to enhance influenza virus… 
2004
2004
Disposition and Metabolic Profiles of [14C]Viramidine and [14C]Ribavirin in Rat and Monkey Red Blood Cells and Liver
ABSTRACT The disposition and metabolic profiles of [14C]viramidine and [14C]ribavirin were compared in rat and monkey red blood… 
Highly Cited
2003
Highly Cited
2003
Activation and Deactivation of a Broad-Spectrum Antiviral Drug by a Single Enzyme: Adenosine Deaminase Catalyzes Two Consecutive Deamination Reactions
ABSTRACT Ribavirin is an approved broad-spectrum antiviral drug. A liver-targeting prodrug of ribavirin, viramidine, is in… 
2003
2003
Pharmacokinetics and Metabolism of [14C]Viramidine in Rats and Cynomolgus Monkeys
ABSTRACT The pharmacokinetics of [14C]viramidine, a prodrug of ribavirin, were studied in rats (30 mg/kg of body weight) and… 
1989
1989
Synthesis and antitumor activity of ribavirin imidates. A new facile synthesis of ribavirin amidine (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine hydrochloride).
Methyl 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboximidate (4) and ethyl 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidate… 
1988
1988
Effects of ribamidine, a 3-carboxamidine derivative of ribavirin, on experimentally induced Phlebovirus infections.
1988
1988
Synthesis and evaluation of 5-amino-1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine and certain related nucleosides as inhibitors of purine nucleoside phosphorylase.
The 5-amino and certain related derivatives of the powerful purine nucleoside phosphorylase (PNPase) inhibitor 1-beta-D… 
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