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reparixin

Known as: (R)-2-(4-isobutylphenyl)propionylmethanesulfonamide, Benzeneacetamide, Alpha-methyl-4-(2-methylpropyl)-N- (methylsulfonyl)- (alphaR)-, Repertaxin 
An orally available inhibitor of CXC chemokine receptor types 1 (CXCR1) and 2 (CXCR2), with potential antineoplastic activity. Upon administration… 
National Institutes of Health

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NCIt Antineoplastic Agent Terminology

Papers overview

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2019
2019
IL‐8 and CXCR1 expression is associated with cancer stem cell‐like properties of clear cell renal cancer
Recent studies suggest that clear cell renal cell carcinoma (ccRCC) possesses a rare population of cancer stem cells (CSCs) that… 
2019
2019
Fenretinide, Tocilizumab, and Reparixin Provide Multifaceted Disruption of Oral Squamous Cell Carcinoma Stem Cell Properties: Implications for Tertiary Chemoprevention
Locoregional recurrence of oral squamous cell carcinoma (OSCC) dramatically reduces patient survival. Further, as many OSCC… 
2018
2018
Interleukin‐8 mediates neutrophil‐endothelial interactions in pig‐to‐human xenogeneic models
Human neutrophils are sequestered by pig lung xenografts within minutes during ex vivo perfusion. This phenomenon is not… 
2017
2017
Loss of dual‐specificity phosphatase‐2 promotes angiogenesis and metastasis via up‐regulation of interleukin‐8 in colon cancer
Dual‐specificity phosphatase 2 (DUSP2) is a negative regulator of mitogen‐activated protein kinases. Our previous study showed… 
2013
2013
Abstract OT2-6-03: A single arm, preoperative, pilot study to evaluate the safety and biological effects of orally administered reparixin in early breast cancer patients who are candidates for…
Background. Experimental models and retrospective clinical observations point to Cancer Stem Cells (CSC) as responsible for tumor… 
2010
2010
Astrocytic activation and an inhibition of MAP kinases are required for proteinase‐activated receptor‐2‐mediated protection from neurotoxicity
J. Neurochem. (2010) 113, 1471–1480. 
2008
2008
406: Comparison of a Tacrolimus/Sirolimus/Prednisone Regimen Versus Tacrolimus/Azathioprine/Prednisone Immunosuppressive Regimen in Lung Transplantation
2007
2007
Pharmacological Characterization of Sch 527123 , a Potent Allosteric CXCR 1 / CXCR 2 Antagonist
In neutrophils, growth-related protein(CXCL1) and interleukin-8 (CXCL8), are potent chemoattractants (Cytokine 14:27– 36, 2001… 
2006
2006
Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1alpha, TNF-alpha and LTB(4).
Neutrophils are thought to play an important role in the tissue damage observed in various autoimmune diseases. Chemokines… 
2006
2006
Development of a systemically-active dual CXCR1/CXCR2 allosteric inhibitor and its efficacy in a model of transient cerebral ischemia in the rat.
The chemokine receptors CXCR1 and CXCR2 present on polymorphonuclear neutrophils (PMN), bind the chemokine CXC ligand 8 (CXCL8… 
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