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reparixin

Known as: (R)-2-(4-isobutylphenyl)propionylmethanesulfonamide, Benzeneacetamide, Alpha-methyl-4-(2-methylpropyl)-N- (methylsulfonyl)- (alphaR)-, Repertaxin 
An orally available inhibitor of CXC chemokine receptor types 1 (CXCR1) and 2 (CXCR2), with potential antineoplastic activity. Upon administration… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Although long considered a promising treatment option for type 1 diabetes, pancreatic islet cell transformation has been hindered… Expand
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2011
2011
STUDY DESIGN Autologous nucleus pulposus obtained from coccygeal intervertebral discs was grafted on the proximal of L5 dorsal… Expand
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Highly Cited
2010
Highly Cited
2010
Recent evidence suggests that breast cancer and other solid tumors possess a rare population of cells capable of extensive self… Expand
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2010
2010
CXCL2 has been known to regulate immune functions mainly by chemo-attracting neutrophils. In this study, we show that CXCL2 can… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE To investigate the mechanism underlying neutrophil migration into the articular cavity in experimental arthritis and… Expand
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2008
2008
BACKGROUND AND PURPOSE Acute lung injury (ALI) remains a major challenge in critical care medicine. Both neutrophils and… Expand
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2007
2007
It has been shown that the blockade of CXCR1 and CXCR2 receptors prevents ischemia/reperfusion damage in several types of… Expand
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2007
2007
Leukocyte infiltration is viewed as a pharmacological target in cerebral ischemia. We previously reported that reparixin, a CXCL8… Expand
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2006
2006
Neutrophils are thought to play an important role in the tissue damage observed in various autoimmune diseases. Chemokines… Expand
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Highly Cited
2004
Highly Cited
2004
The chemokine CXC ligand 8 (CXCL8)/IL-8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC… Expand
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