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reparixin

Known as: (R)-2-(4-isobutylphenyl)propionylmethanesulfonamide, Benzeneacetamide, Alpha-methyl-4-(2-methylpropyl)-N- (methylsulfonyl)- (alphaR)-, Repertaxin 
An orally available inhibitor of CXC chemokine receptor types 1 (CXCR1) and 2 (CXCR2), with potential antineoplastic activity. Upon administration… Expand
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Purpose: Chemokine receptor 1 (CXCR1) is recognized as an actionable receptor selectively expressed by breast cancer stem cells… Expand
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Highly Cited
2010
Highly Cited
2010
Recent evidence suggests that breast cancer and other solid tumors possess a rare population of cells capable of extensive self… Expand
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Highly Cited
2009
Highly Cited
2009
IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the… Expand
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Highly Cited
2009
Highly Cited
2009
Background and purpose:  Chemokines orchestrate neutrophil recruitment to inflammatory foci. In the present study, we evaluated… Expand
Highly Cited
2008
Highly Cited
2008
Acute lung injury (ALI) remains a major challenge in critical care medicine. Both neutrophils and chemokines have been proposed… Expand
Highly Cited
2008
Highly Cited
2008
OBJECTIVE To investigate the mechanism underlying neutrophil migration into the articular cavity in experimental arthritis and… Expand
Highly Cited
2005
Highly Cited
2005
BACKGROUND Ischemia/reperfusion (I/R) injury after organ transplantation is a major cause of delayed graft function. Following I… Expand
Highly Cited
2005
Highly Cited
2005
The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at… Expand
Highly Cited
2004
Highly Cited
2004
The chemokine CXC ligand 8 (CXCL8)/IL-8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC… Expand
Highly Cited
2004
Highly Cited
2004
Neutrophils are thought to play a major role in the mediation of reperfusion injury. CXC chemokines are known inducers of… Expand