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reparixin

Known as: (R)-2-(4-isobutylphenyl)propionylmethanesulfonamide, Benzeneacetamide, Alpha-methyl-4-(2-methylpropyl)-N- (methylsulfonyl)- (alphaR)-, Repertaxin 
An orally available inhibitor of CXC chemokine receptor types 1 (CXCR1) and 2 (CXCR2), with potential antineoplastic activity. Upon administration… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
CXCR1/2 inhibition enhances pancreatic islet survival after transplantation.
Although long considered a promising treatment option for type 1 diabetes, pancreatic islet cell transformation has been hindered… Expand
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2011
2011
Changes in expression of mRNA for interleukin-8 and effects of interleukin-8 receptor inhibitor in the spinal dorsal horn in a rat model of lumbar disc herniation.
STUDY DESIGN Autologous nucleus pulposus obtained from coccygeal intervertebral discs was grafted on the proximal of L5 dorsal… Expand
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Highly Cited
2010
Highly Cited
2010
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.
Recent evidence suggests that breast cancer and other solid tumors possess a rare population of cells capable of extensive self… Expand
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2010
2010
CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesis.
CXCL2 has been known to regulate immune functions mainly by chemo-attracting neutrophils. In this study, we show that CXCL2 can… Expand
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Highly Cited
2008
Highly Cited
2008
CXCR2-specific chemokines mediate leukotriene B4-dependent recruitment of neutrophils to inflamed joints in mice with antigen-induced arthritis.
OBJECTIVE To investigate the mechanism underlying neutrophil migration into the articular cavity in experimental arthritis and… Expand
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2008
2008
Therapeutic inhibition of CXCR2 by Reparixin attenuates acute lung injury in mice.
BACKGROUND AND PURPOSE Acute lung injury (ALI) remains a major challenge in critical care medicine. Both neutrophils and… Expand
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2007
2007
Reparixin, an inhibitor of CXCR2 function, attenuates inflammatory responses and promotes recovery of function after traumatic lesion to the spinal cord.
It has been shown that the blockade of CXCR1 and CXCR2 receptors prevents ischemia/reperfusion damage in several types of… Expand
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2007
2007
The Interleukin-8 (IL-8/CXCL8) Receptor Inhibitor Reparixin Improves Neurological Deficits and Reduces Long-term Inflammation in Permanent and Transient Cerebral Ischemia in Rats
Leukocyte infiltration is viewed as a pharmacological target in cerebral ischemia. We previously reported that reparixin, a CXCL8… Expand
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2006
2006
Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1alpha, TNF-alpha and LTB(4).
Neutrophils are thought to play an important role in the tissue damage observed in various autoimmune diseases. Chemokines… Expand
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Highly Cited
2004
Highly Cited
2004
Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.
The chemokine CXC ligand 8 (CXCL8)/IL-8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC… Expand
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