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reparixin

Known as: (R)-2-(4-isobutylphenyl)propionylmethanesulfonamide, Benzeneacetamide, Alpha-methyl-4-(2-methylpropyl)-N- (methylsulfonyl)- (alphaR)-, Repertaxin 
An orally available inhibitor of CXC chemokine receptor types 1 (CXCR1) and 2 (CXCR2), with potential antineoplastic activity. Upon administration… Expand
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Purpose: Chemokine receptor 1 (CXCR1) is recognized as an actionable receptor selectively expressed by breast cancer stem cells… Expand
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Highly Cited
2011
Highly Cited
2011
Background Chronic neutrophilic inflammation is a poorly understood feature in a variety of diseases with notable worldwide… Expand
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Highly Cited
2010
Highly Cited
2010
Recent evidence suggests that breast cancer and other solid tumors possess a rare population of cells capable of extensive self… Expand
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Highly Cited
2009
Highly Cited
2009
IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE To investigate the mechanism underlying neutrophil migration into the articular cavity in experimental arthritis and… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Ischemia/reperfusion (I/R) injury after organ transplantation is a major cause of delayed graft function. Following I… Expand
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Highly Cited
2005
Highly Cited
2005
The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at… Expand
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Highly Cited
2005
Highly Cited
2005
Repertaxin is a new non-competitive allosteric blocker of interleukin-8 (CXCL8/IL-8) receptors (CXCR1/R2), which by locking CXCR1… Expand
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Highly Cited
2004
Highly Cited
2004
The chemokine CXC ligand 8 (CXCL8)/IL-8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC… Expand
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Highly Cited
2004
Highly Cited
2004
Neutrophils are thought to play a major role in the mediation of reperfusion injury. CXC chemokines are known inducers of… Expand
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