receptor antagonist activity

Interacts with receptors to reduce the action of another ligand, the agonist. [GOC:ceb, ISBN:0198506732]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2018
05101519792018

Papers overview

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2010
2010
A number of known 1,4-dihydropyridine CCBs were identified as having comparable potency to the steroidal MR antagonist eplerenone… (More)
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2008
2008
Calcium channel blockers are widely used antihypertensives. Mineralocorticoid receptor antagonists are also used to treat… (More)
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2002
2002
Bile salt export pump (BSEP) is a major bile acid transporter in the liver. Mutations in BSEP result in progressive intrahepatic… (More)
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2000
2000
1. We have investigated the pharmacological properties of LY344545, a structurally related epimer of the broad spectrum… (More)
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Highly Cited
1997
Highly Cited
1997
The chromogranins comprise a class of acidic proteins that are secreted from large dense core vesicles and expressed in neuronal… (More)
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1997
1997
L-745,870,(3-([4-(4-chlorophenyl)piperazin-1-yl]methyl)-1H- pyrollo[2,3-b] pyridine, was identified as a selective dopamine D4… (More)
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Highly Cited
1997
Highly Cited
1997
Amisulpride, a benzamide derivative, is an antipsychotic drug with a pharmacological profile distinct from that of classical… (More)
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1996
1996
A number of studies have examined the structure-activity relationships for the agonist activity of Ah receptor (AhR) ligands… (More)
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Highly Cited
1990
Highly Cited
1990
Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence… (More)
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1987
1987
Buprenorphine was studied for its effects on urinary output to determine if it was an agonist, partial agonist, or antagonist at… (More)
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