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pyrrolotriazine-4-one

 
National Institutes of Health

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PyrrolesTriazines

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2009
2009
Assessing compound binding to the Eg5 motor domain using a thermal shift assay.
Eg5 is a kinesin whose inhibition leads to cycle arrest during mitosis, making it a potential therapeutic target in cancers… Expand
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2006
2006
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.
Synthesis and SAR of substituted pyrrolotriazine-4-one analogues as Eg5 inhibitors are described. Many of these analogues… Expand
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