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pyrrolobenzodiazepine

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
DNA sequence-selective C 8-linked pyrrolobenzodiazepine ( PBD )-heterocyclic polyamide 1 conjugates show anti-tubercular specific activities 2
Author Affiliations 5 School of Science, Institute of Biomedical and Environmental Health Research (IBEHR), University of 6 the… 
2015
2015
Interaction of Pyrrolobenzodiazepine conjugates with DNA
Pyrrolobenzodiazepines (PBD) are a group of naturally occurring antitumor antibiotics that consist of a tricyclic system… 
2013
2013
Comment on Stowell et al , page 1494 A mouse model of hemolytic disease of the newborn-----------------------------------------------------------------------------------------------------Chance
A t this time, there is a void in the field of antibody–drug conjugates (ADC) targeting CD33 as a therapeutic option for… 
2011
2011
Synthesis of Aryl‐Substituted Naphthalene‐Linked Pyrrolobenzodiazepine Conjugates as Potential Anticancer Agents with Apoptosis‐Inducing Ability
A library of new aryl‐substituted naphthalene C8‐linked pyrrolo[2,1‐c][1,4]benzodiazepine (PBD) conjugates with various linker… 
2005
2005
Influence of P-glycoprotein expression on cytotoxicity and antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136
SJG-136 is a novel pyrrolobenzodiazepine dimer analogue that acts as a minor-groove interstrand DNA cross-linking agent. The… 
2005
2005
Therapeutic composition comprising at least one pyrrolobenzodiazepine derivative and a fludarabine
The present invention at least one of the pyrrolobenzodiazepine derivative contained in combination with fludarabine comprising… 
2004
2004
Pharmacological characterisation of selected pyrrolobenzodiazepines as anti-cancer agents : pharmacokinetic and pharmacodynamic characterisation of the pyrrolobenzodiazepine dimer SJG-136 and the…
This study aimed to investigate the pharmacology of selected pyrrolobenzodiazepine (PBD) compounds shown to have cytotoxic… 
2004
2004
Therapeutic composition containing at least a derivative of the pyrrolobenzodiazepine and fludarabine
This invention relates to the use of a therapeutic composition comprising at least one pyrrolobenzodiazepine derivative in… 
2002
2002
In vitro antitumor activity and in vivo DNA interstrand crosslinking by the novel pyrrolobenzodiazepine dimer SJG-136 (NSC 694501)
1993
1993
Derives de pyrrolobenzodiazepine anti-cancereux
L'invention concerne des nouveaux composes, des dimeres de pyrrolo [2,1-c][1,4] benzodiazepine (PBD) de formule (I) dans laquelle…