pyrrolobenzodiazepine

 
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a family of sequence-selective DNA minor-groove binding agents that form a… (More)
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Highly Cited
2015
Highly Cited
2015
The high-grade pulmonary neuroendocrine tumors, small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC… (More)
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Highly Cited
2013
Highly Cited
2013
Outcomes in acute myeloid leukemia (AML) remain unsatisfactory, and novel treatments are urgently needed. One strategy explores… (More)
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Highly Cited
2013
Highly Cited
2013
A highly cytotoxic DNA cross-linking pyrrolobenzodiazepine (PBD) dimer with a valine-alanine dipeptide linker was conjugated to… (More)
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2011
2011
Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers are synthetic sequence-selective DNA minor-groove cross-linking agents that… (More)
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2011
2011
A series of novel DNA-interactive C8-linked pyrrolobenzodiazepine (PBD)-heterocycle polyamide conjugates has been synthesised to… (More)
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2010
2010
The pyrrolobenzodiazepines (PBD) are naturally occurring antitumor antibiotics, and a PBD dimer (SJG-136, SG2000) is in phase II… (More)
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2008
2008
1,2,3-Triazole based molecules are useful pharmacophores for several DNA-alkylating and cross-linking agents. A series of A/C8, C… (More)
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2008
2008
Many genes involved in cell cycle control have promoters that bind the heterotrimeric transcription factor NF-Y. Several minor… (More)
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1990
1990
Streptomyces griseus and bacteriophage B were used for an assay system detecting anti-bacteriophage antibiotics. Streptomyces sp… (More)
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