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Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus… Expand Leishmania parasites are pteridine auxotrophs that use an NADPH-dependent pteridine reductase 1 (PTR1) and NADH-dependent… Expand Genetic studies indicate that the enzyme pteridine reductase 1 (PTR1) is essential for the survival of the protozoan parasite… Expand Activity of the pterin- and folate-salvaging enzymes pteridine reductase 1 (PTR1) and dihydrofolate reductase–thymidylate… Expand The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual… Expand Background Recent circumstantial evidence suggests that an increasing number of Iranian patients with cutaneous leishmaniasis are… Expand Pteridine metabolism in Trypanosoma cruzi is poorly understood. The term ‘pteridine’ is used collectively for two classes of… Expand The enzyme pteridine reductase (PTR1) has recently been discovered in the protozoan parasite Leishmania and validated as a target… Expand Pteridine reductase 1 (PTR1) is a novel broad spectrum enzyme of pterin and folate metabolism in the protozoan parasite… Expand Leishmania and other trypanosomatid protozoa require reduced pteridines (pterins and folates) for growth, suggesting that… Expand