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pteridine reductase 1

Known as: PTR1 pteridine reductase 
National Institutes of Health

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pteridine reductase

Papers overview

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2017
2017
Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity
Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus… 
Highly Cited
2016
Highly Cited
2016
Structure based medicinal chemistry-driven strategy to design substituted dihydropyrimidines as potential antileishmanial agents.
2011
2011
Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major*
Leishmania parasites are pteridine auxotrophs that use an NADPH-dependent pteridine reductase 1 (PTR1) and NADH-dependent… 
2011
2011
Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1
Genetic studies indicate that the enzyme pteridine reductase 1 (PTR1) is essential for the survival of the protozoan parasite… 
2010
2010
In Silico Screening, Structure-Activity Relationship, and Biologic Evaluation of Selective Pteridine Reductase Inhibitors Targeting Visceral Leishmaniasis
ABSTRACT In this study we utilized the concept of rational drug design to identify novel compounds with optimal selectivity… 
Highly Cited
2009
Highly Cited
2009
One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening†
The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual… 
Highly Cited
2006
Highly Cited
2006
Unresponsiveness to Glucantime Treatment in Iranian Cutaneous Leishmaniasis due to Drug-Resistant Leishmania tropica Parasites
Background Recent circumstantial evidence suggests that an increasing number of Iranian patients with cutaneous leishmaniasis are… 
1999
1999
Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1).
The enzyme pteridine reductase (PTR1) has recently been discovered in the protozoan parasite Leishmania and validated as a target… 
1998
1998
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence.
Pteridine reductase 1 (PTR1) is a novel broad spectrum enzyme of pterin and folate metabolism in the protozoan parasite… 
Review
1997
Review
1997
New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity
Leishmania and other trypanosomatid protozoa require reduced pteridines (pterins and folates) for growth, suggesting that… 
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