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pteridine reductase 1

Known as: PTR1 pteridine reductase 
National Institutes of Health

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pteridine reductase

Papers overview

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2017
2017
Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity
Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus… Expand
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2011
2011
Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major*
Leishmania parasites are pteridine auxotrophs that use an NADPH-dependent pteridine reductase 1 (PTR1) and NADH-dependent… Expand
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2011
2011
Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1
Genetic studies indicate that the enzyme pteridine reductase 1 (PTR1) is essential for the survival of the protozoan parasite… Expand
2010
2010
Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase
Activity of the pterin- and folate-salvaging enzymes pteridine reductase 1 (PTR1) and dihydrofolate reductase–thymidylate… Expand
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Highly Cited
2009
Highly Cited
2009
One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening†
The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual… Expand
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Highly Cited
2006
Highly Cited
2006
Unresponsiveness to Glucantime Treatment in Iranian Cutaneous Leishmaniasis due to Drug-Resistant Leishmania tropica Parasites
Background Recent circumstantial evidence suggests that an increasing number of Iranian patients with cutaneous leishmaniasis are… Expand
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2003
2003
Trypanosoma cruzi genome encodes a pteridine reductase 2 protein.
Pteridine metabolism in Trypanosoma cruzi is poorly understood. The term ‘pteridine’ is used collectively for two classes of… Expand
1999
1999
Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1).
The enzyme pteridine reductase (PTR1) has recently been discovered in the protozoan parasite Leishmania and validated as a target… Expand
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1998
1998
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence.
Pteridine reductase 1 (PTR1) is a novel broad spectrum enzyme of pterin and folate metabolism in the protozoan parasite… Expand
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Review
1997
Review
1997
New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity.
Leishmania and other trypanosomatid protozoa require reduced pteridines (pterins and folates) for growth, suggesting that… Expand
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