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pteridine reductase 1
Known as:
PTR1 pteridine reductase
National Institutes of Health
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pteridine reductase
Papers overview
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2017
2017
Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity
F. Di Pisa
,
G. Landi
,
+17 authors
S. Mangani
Molecules
2017
Corpus ID: 15847499
Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus…
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Highly Cited
2016
Highly Cited
2016
Structure based medicinal chemistry-driven strategy to design substituted dihydropyrimidines as potential antileishmanial agents.
U. Rashid
,
R. Sultana
,
+9 authors
N. Qureshi
European journal of medicinal chemistry
2016
Corpus ID: 39510314
2011
2011
Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major*
H. Ong
,
N. Sienkiewicz
,
S. Wyllie
,
A. Fairlamb
The Journal of Biological Chemistry
2011
Corpus ID: 13919675
Leishmania parasites are pteridine auxotrophs that use an NADPH-dependent pteridine reductase 1 (PTR1) and NADH-dependent…
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2011
2011
Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1
D. Spinks
,
H. Ong
,
+9 authors
I. Gilbert
ChemMedChem
2011
Corpus ID: 3889778
Genetic studies indicate that the enzyme pteridine reductase 1 (PTR1) is essential for the survival of the protozoan parasite…
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2010
2010
In Silico Screening, Structure-Activity Relationship, and Biologic Evaluation of Selective Pteridine Reductase Inhibitors Targeting Visceral Leishmaniasis
J. Kaur
,
P. Kumar
,
+4 authors
Neeloo Singh
Antimicrobial Agents and Chemotherapy
2010
Corpus ID: 6568655
ABSTRACT In this study we utilized the concept of rational drug design to identify novel compounds with optimal selectivity…
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Highly Cited
2009
Highly Cited
2009
One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening†
C. Mpamhanga
,
D. Spinks
,
+9 authors
R. Brenk
Journal of medicinal chemistry
2009
Corpus ID: 13951552
The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual…
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Highly Cited
2006
Highly Cited
2006
Unresponsiveness to Glucantime Treatment in Iranian Cutaneous Leishmaniasis due to Drug-Resistant Leishmania tropica Parasites
R. Hadighi
,
M. Mohebali
,
P. Boucher
,
H. Hajjaran
,
A. Khamesipour
,
M. Ouellette
PLoS medicine
2006
Corpus ID: 7730524
Background Recent circumstantial evidence suggests that an increasing number of Iranian patients with cutaneous leishmaniasis are…
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1999
1999
Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1).
D. G. Gourley
,
J. Luba
,
L. Hardy
,
S. Beverley
,
W. Hunter
Acta crystallographica. Section D, Biological…
1999
Corpus ID: 7630440
The enzyme pteridine reductase (PTR1) has recently been discovered in the protozoan parasite Leishmania and validated as a target…
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1998
1998
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence.
J. Luba
,
B. Nare
,
P. Liang
,
K. Anderson
,
S. Beverley
,
L. Hardy
Biochemistry
1998
Corpus ID: 30365461
Pteridine reductase 1 (PTR1) is a novel broad spectrum enzyme of pterin and folate metabolism in the protozoan parasite…
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Review
1997
Review
1997
New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity
B. Nare
,
J. Luba
,
L. Hardy
,
S. Beverley
Parasitology
1997
Corpus ID: 569807
Leishmania and other trypanosomatid protozoa require reduced pteridines (pterins and folates) for growth, suggesting that…
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