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pteridine reductase 1

Known as: PTR1 pteridine reductase 
 
National Institutes of Health

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pteridine reductase

Papers overview

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2011
2011
Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major*
Leishmania parasites are pteridine auxotrophs that use an NADPH-dependent pteridine reductase 1 (PTR1) and NADH-dependent… Expand
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2011
2011
In silico screening, structure-activity relationship, and biologic evaluation of selective pteridine reductase inhibitors targeting visceral leishmaniasis.
In this study we utilized the concept of rational drug design to identify novel compounds with optimal selectivity, efficacy and… Expand
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2010
2010
Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase
Activity of the pterin- and folate-salvaging enzymes pteridine reductase 1 (PTR1) and dihydrofolate reductase–thymidylate… Expand
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Highly Cited
2009
Highly Cited
2009
One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening†
The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual… Expand
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2009
2009
An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1
The protozoan parasite Leishmania donovani is the causative agent of visceral leishmaniasis. The enzyme pteridine reductase 1… Expand
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2007
2007
Degradation of pteridine reductase 1 (PTR1) enzyme during growth phase in the protozoan parasite Leishmania donovani.
Pteridine reductase 1 (PTR1) is an essential enzyme of pterin and folate metabolism in the protozoan parasite Leishmania. The… Expand
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Highly Cited
2006
Highly Cited
2006
Unresponsiveness to Glucantime Treatment in Iranian Cutaneous Leishmaniasis due to Drug-Resistant Leishmania tropica Parasites
Background Recent circumstantial evidence suggests that an increasing number of Iranian patients with cutaneous leishmaniasis are… Expand
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1999
1999
Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1).
The enzyme pteridine reductase (PTR1) has recently been discovered in the protozoan parasite Leishmania and validated as a target… Expand
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1998
1998
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence.
Pteridine reductase 1 (PTR1) is a novel broad spectrum enzyme of pterin and folate metabolism in the protozoan parasite… Expand
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Review
1997
Review
1997
New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity.
Leishmania and other trypanosomatid protozoa require reduced pteridines (pterins and folates) for growth, suggesting that… Expand
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