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pteridine reductase 1

Known as: PTR1 pteridine reductase 
National Institutes of Health

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pteridine reductase

Papers overview

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2019
2019
2-Aryl-quinazolin-4(3H)-ones as an inhibitor of leishmania folate pathway: In vitro biological evaluation, mechanism studies and molecular docking.
2017
2017
In silico molecular docking studies of new potential 4-phthalazinyl-hydrazones on selected Trypanosoma cruzi and Leishmania enzyme targets.
Highly Cited
2016
Highly Cited
2016
Structure based medicinal chemistry-driven strategy to design substituted dihydropyrimidines as potential antileishmanial agents.
2010
2010
In Silico Screening, Structure-Activity Relationship, and Biologic Evaluation of Selective Pteridine Reductase Inhibitors Targeting Visceral Leishmaniasis
ABSTRACT In this study we utilized the concept of rational drug design to identify novel compounds with optimal selectivity… 
2010
2010
Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase
2009
2009
An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1
The protozoan parasite Leishmania donovani is the causative agent of visceral leishmaniasis. The enzyme pteridine reductase 1… 
2005
2005
Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor.
2003
2003
Trypanosoma cruzi genome encodes a pteridine reductase 2 protein.
Highly Cited
2001
Highly Cited
2001
Regulation of Differentiation to the Infective Stage of the Protozoan Parasite Leishmania major by Tetrahydrobiopterin
A critical step in the infectious cycle of Leishmania is the differentiation of parasites within the sand fly vector to the… 
1998
1998
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence.
Pteridine reductase 1 (PTR1) is a novel broad spectrum enzyme of pterin and folate metabolism in the protozoan parasite… 
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