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pteridine reductase 1

Known as: PTR1 pteridine reductase 
 
National Institutes of Health

Papers overview

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2011
2011
Leishmania parasites are pteridine auxotrophs that use an NADPH-dependent pteridine reductase 1 (PTR1) and NADH-dependent… Expand
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2011
2011
In this study we utilized the concept of rational drug design to identify novel compounds with optimal selectivity, efficacy and… Expand
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2010
2010
Activity of the pterin- and folate-salvaging enzymes pteridine reductase 1 (PTR1) and dihydrofolate reductase–thymidylate… Expand
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Highly Cited
2009
Highly Cited
2009
The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual… Expand
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2009
2009
The protozoan parasite Leishmania donovani is the causative agent of visceral leishmaniasis. The enzyme pteridine reductase 1… Expand
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2007
2007
Pteridine reductase 1 (PTR1) is an essential enzyme of pterin and folate metabolism in the protozoan parasite Leishmania. The… Expand
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Highly Cited
2006
Highly Cited
2006
Background Recent circumstantial evidence suggests that an increasing number of Iranian patients with cutaneous leishmaniasis are… Expand
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1999
1999
The enzyme pteridine reductase (PTR1) has recently been discovered in the protozoan parasite Leishmania and validated as a target… Expand
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1998
1998
Pteridine reductase 1 (PTR1) is a novel broad spectrum enzyme of pterin and folate metabolism in the protozoan parasite… Expand
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Review
1997
Review
1997
Leishmania and other trypanosomatid protozoa require reduced pteridines (pterins and folates) for growth, suggesting that… Expand
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