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pteridine reductase 1

Known as: PTR1 pteridine reductase 
National Institutes of Health

Papers overview

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2017
2017
Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus… 
Highly Cited
2016
2011
2011
Leishmania parasites are pteridine auxotrophs that use an NADPH-dependent pteridine reductase 1 (PTR1) and NADH-dependent… 
2011
2011
Genetic studies indicate that the enzyme pteridine reductase 1 (PTR1) is essential for the survival of the protozoan parasite… 
2010
2010
ABSTRACT In this study we utilized the concept of rational drug design to identify novel compounds with optimal selectivity… 
Highly Cited
2009
Highly Cited
2009
The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual… 
Highly Cited
2006
Highly Cited
2006
Background Recent circumstantial evidence suggests that an increasing number of Iranian patients with cutaneous leishmaniasis are… 
1999
1999
The enzyme pteridine reductase (PTR1) has recently been discovered in the protozoan parasite Leishmania and validated as a target… 
1998
1998
Pteridine reductase 1 (PTR1) is a novel broad spectrum enzyme of pterin and folate metabolism in the protozoan parasite… 
Review
1997
Review
1997
Leishmania and other trypanosomatid protozoa require reduced pteridines (pterins and folates) for growth, suggesting that…