prucalopride

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
010203019992017

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2010
2010
BACKGROUND Constipation affects up to 50% of the elderly; this study evaluates the efficacy, safety, and tolerability of the… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE To determine the efficacy, impact on quality of life (QOL) and safety of prucalopride, a selective, high-affinity 5-HT… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Chronic constipation may result in disabling symptoms, is often unsatisfactorily treated by laxatives and negatively… (More)
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2009
2009
Chronic constipation is common among nursing home residents. The aim of this study was to evaluate safety, tolerability and… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND In this 12-week trial, we aimed to determine the efficacy of prucalopride, a selective, high-affinity 5… (More)
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2008
2008
It is known that 5-HT(4) receptor agonists increase sAPPalpha levels in the cortex and hippocampus of mice as well as in a model… (More)
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2002
2002
BACKGROUND There is a need for better tolerated drugs to normalize bowel function in chronic constipation. Prucalopride is a… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND & AIMS Prucalopride (PRU) is a selective benzofuran 5-hydroxytryptamine(4)-receptor agonist with gastrointestinal and… (More)
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2001
2001
The novel enterokinetic drug prucalopride was tested at various intravenous and oral doses in fasted dogs to assess: (i) the… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Prucalopride (R093877) is a selective and specific 5HT4 agonist, the first of a new chemical class of benzofurans… (More)
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