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protein polyubiquitination

Known as: protein polyubiquitinylation, protein polyubiquitylation 
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. [ISBN:0815316194]
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2018
012320012018

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3 relations
negative regulation of protein polyubiquitinationpolyubiquitin activitypositive regulation of protein polyubiquitination

Related mentions per year

Related mentions per year

1991-2018
1990200020102020
protein polyubiquitination
polyubiquitin activity
negative regulation of protein polyubiquitination
positive regulation of protein polyubiquitination

Papers overview

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Review
2017
Review
2017
Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology.
AIMS Among the putative mechanisms proposed to be common factors in Down syndrome (DS) and Alzheimer's disease (AD… (More)
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2016
2016
Formaldehyde Is a Potent Proteotoxic Stressor Causing Rapid Heat Shock Transcription Factor 1 Activation and Lys48-Linked Polyubiquitination of Proteins.
Endogenous and exogenous formaldehyde (FA) has been linked to cancer, neurotoxicity, and other pathophysiologic effects… (More)
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2014
2014
Chemical protein polyubiquitination reveals the role of a noncanonical polyubiquitin chain in DNA damage tolerance.
Polyubiquitination of proteins regulates a variety of cellular processes, including protein degradation, NF-κB pathway activation… (More)
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2013
2013
Altered reactivity of tertiary mesenteric arteries following acute myocardial ischemia.
BACKGROUND It is unknown if cardiac ischemia has any deleterious effect on the contractile properties of nonischemic, peripheral… (More)
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2013
2013
CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories
CaMKII and Protein Kinase A (PKA) are thought to be critical for synaptic plasticity and memory formation through their… (More)
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2013
2013
Ubiquitin-proteasome system, a new anti-tumor target
U system (UPS) is a major pathway for intracellular protein degradation. Its target proteins include a broad array of regulatory… (More)
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2012
2012
Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation.
Proinflammatory M1 activation of hepatic macrophages (HM) is critical in pathogenesis of hepatitis, but its mechanisms are still… (More)
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2008
2008
Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3.
The final outcome of protein polyubiquitylation is often proteasome-mediated proteolysis, meaning that "proofreading" of… (More)
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2008
2008
Brain-derived neurotrophic factor-tropomyosin-related kinase B signaling contributes to activity-dependent changes in synaptic proteins.
The ability of synapses to undergo changes in structure and function in response to alterations of neuronal activity is an… (More)
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Highly Cited
2001
Highly Cited
2001
NEDD8 recruits E2-ubiquitin to SCF E3 ligase.
NEDD8/Rub1 is a ubiquitin (Ub)-like post-translational modifier that is covalently linked to cullin (Cul)-family proteins in a… (More)
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