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proteasome activator complex location

Known as: PA28, proteasome activator complex 
A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex. [GOC:rb]
National Institutes of Health

Papers overview

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Review
2005
Review
2005
Interferon‐γ, the functional plasticity of the ubiquitin–proteasome system, and MHC class I antigen processing
Summary:  The proteasome system is a central component of a cascade of proteolytic processing steps required to generate… Expand
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Review
2004
Review
2004
Proteasome and peptidase function in MHC-class-I-mediated antigen presentation.
MHC-class-I-presented peptides are predominantly generated by the proteasome system. IFN-gamma strongly influences the processing… Expand
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Highly Cited
2003
Highly Cited
2003
Altered Proteasomal Function in Sporadic Parkinson's Disease
Parkinson's disease (PD) is characterized pathologically by preferential degeneration of the dopaminergic neurons in the… Expand
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Review
2002
Review
2002
The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides.
Three different proteolytic processes have been shown to be important in the generation of antigenic peptides displayed on MHC… Expand
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Review
2001
Review
2001
Role and fate of PML nuclear bodies in response to interferon and viral infections
Interferons (IFNs) are a family of secreted proteins with antiviral, antiproliferative and immunomodulatory activities. The… Expand
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Highly Cited
2000
Highly Cited
2000
Structural basis for the activation of 20S proteasomes by 11S regulators
Most of the non-lysosomal proteolysis that occurs in eukaryotic cells is performed by a nonspecific and abundant barrel-shaped… Expand
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Highly Cited
1999
Highly Cited
1999
Dynamic Association of Proteasomal Machinery with the Centrosome
Although the number of pathologies known to arise from the inappropriate folding of proteins continues to grow, mechanisms… Expand
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Review
1998
Review
1998
Mechanisms of MHC class I--restricted antigen processing.
Classical class I molecules assemble in the endoplasmic reticulum (ER) with peptides mostly generated from cytosolic proteins by… Expand
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Highly Cited
1996
Highly Cited
1996
A role for the proteasome regulator PA28α in antigen presentation
CYTOTOXIC T cells recognize viral proteins as peptide fragments which are produced in the cytosol and transported on major… Expand
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Highly Cited
1992
Highly Cited
1992
Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).
A protein that greatly stimulates the multiple peptidase activities of the 20 S proteasome (also known as macropain, the… Expand
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