proteasome activator complex location

Known as: PA28, proteasome activator complex 
A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex. [GOC:rb]
National Institutes of Health

Papers overview

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Review
2005
Review
2005
Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.
The proteasome system is a central component of a cascade of proteolytic processing steps required to generate antigenic peptides… (More)
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Highly Cited
2005
Highly Cited
2005
Altered proteasome structure, function, and oxidation in aged muscle.
The proteasome is the main protease for degrading oxidized proteins. We asked whether altered proteasome function contributes to… (More)
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Review
2004
Review
2004
Proteasome and peptidase function in MHC-class-I-mediated antigen presentation.
MHC-class-I-presented peptides are predominantly generated by the proteasome system. IFN-gamma strongly influences the processing… (More)
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Highly Cited
2003
Highly Cited
2003
Altered Proteasomal Function in Sporadic Parkinson's Disease
Parkinson's disease (PD) is characterized pathologically by preferential degeneration of the dopaminergic neurons in the… (More)
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Review
2002
Review
2002
The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides.
Three different proteolytic processes have been shown to be important in the generation of antigenic peptides displayed on MHC… (More)
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Highly Cited
2000
Highly Cited
2000
Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.
Proteasomes can exist in several different molecular forms in mammalian cells. The core 20S proteasome, containing the… (More)
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Highly Cited
2000
Highly Cited
2000
Structural basis for the activation of 20S proteasomes by 11S regulators
Most of the non-lysosomal proteolysis that occurs in eukaryotic cells is performed by a nonspecific and abundant barrel-shaped… (More)
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Highly Cited
2000
Highly Cited
2000
Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis.
Eukaryotic cells contain various types of proteasomes. Core 20 S proteasomes (abbreviated 20 S below) have two binding sites for… (More)
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Highly Cited
1999
Highly Cited
1999
Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation.
Dendritic cells (DC) are highly specialized professional antigen presenting cells which are pivotal for the initiation and… (More)
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Review
1998
Review
1998
Mechanisms of MHC class I--restricted antigen processing.
Classical class I molecules assemble in the endoplasmic reticulum (ER) with peptides mostly generated from cytosolic proteins by… (More)
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