prostanoid biosynthetic process

Known as: prostanoid synthesis, prostanoid anabolism, prostanoid biosynthesis 
The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure. [GOC… (More)
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.
Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis William L. Smith,* Yoshihiro Urade, and Per-Johan Jakobsson… (More)
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Review
2003
Review
2003
VEGF signalling: integration and multi-tasking in endothelial cell biology.
The central role of VEGF (vascular endothelial growth factor A) in angiogenesis is dependent upon its ability to co-ordinately… (More)
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Highly Cited
2003
Highly Cited
2003
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.
Despite the importance of prostaglandins, little is known about the regulation of prostanoid synthesis proximal to the activation… (More)
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Review
2002
Review
2002
Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets.
Advances in our understanding of the synthesis, regulation and function of prostanoids have led to a new appreciation of their… (More)
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Review
2001
Review
2001
Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs.
The two isoforms of cyclooxygenase (COX) catalyze the initial step in the formation of biologically important prostanoids, such… (More)
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Highly Cited
2001
Highly Cited
2001
Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2.
The two cyclooxygenase (COX) isoforms, COX-1 and COX-2, both metabolize arachidonic acid to PGH(2), the common substrate for… (More)
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Highly Cited
2001
Highly Cited
2001
Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice.
The cyclooxygenase (COX) product, prostacyclin (PGI(2)), inhibits platelet activation and vascular smooth-muscle cell migration… (More)
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Review
1996
Review
1996
Oxidative stress and diabetic vascular complications.
Long-term vascular complications still represent the main cause of morbidity and mortality in diabetic patients. Although… (More)
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Highly Cited
1995
Highly Cited
1995
Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures.
We have used purified microglial cultures obtained from neonatal rat cerebral cortex to investigate the ability of microglia to… (More)
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Review
1991
Review
1991
Prostaglandin and thromboxane biosynthesis.
We describe the enzymological regulation of the formation of prostaglandin (PG) D2, PGE2, PGF2 alpha, 9 alpha, 11 beta-PGF2, PGI2… (More)
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