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The discovery of acyclovir and penciclovir has led to the development of a successful systemic therapy for treating herpes… Expand Importance
Current therapy of herpes infections relies on nucleoside analogues. Pritelivir is a well-tolerated novel herpes… Expand A mathematical model for antiviral clinical trials improves dose selection and understanding of drug-virus interaction. Dosing… Expand Herpes simplex virus (HSV) types 1 and 2 can cause infections with clinical manifestations ranging from benign and generally self… Expand Background. Pritelivir is a novel helicase-primase inhibitor in clinical development for treatment of herpes simplex virus type 2… Expand The seminal discovery of acyclovir 40 years ago heralded the modern era of truly selective antiviral therapies and this drug… Expand BACKGROUND
Pritelivir, an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal… Expand 1. Balcells ME, Thomas SL, Godfrey-Faussett P, Grant AD. Isoniazid preventive therapy and risk for resistant tuberculosis. Emerg… Expand This review starts with a brief description of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), the clinical diseases they… Expand Fifty-nine US isolates of HSV-1 and HSV-2 obtained between 1998 and 2004 were tested for sensitivity to the helicase-primase… Expand