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The tumor microenvironment is a complex ecology of cells that evolves with and provides support to tumor cells during the… Expand Purpose: Gene expression analysis identifies several breast cancer subtypes. We examined the relationship of neoadjuvant… Expand The concept of tumor stem cells (TSCs) provides a new paradigm for understanding tumor biology, although it remains unclear… Expand Functions of individual matrix metalloproteinases (MMPs) differentially expressed by tumor cells and stromal cells, are finely… Expand BACKGROUND
Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… Expand Metastasis is a multistep process during which cancer cells disseminate from the site of primary tumors and establish secondary… Expand Metastasis is the principal event leading to death in individuals with cancer, yet its molecular basis is poorly understood. To… Expand Revisions in stage grouping of the TNM subsets (T=primary tumor, N=regional lymph nodes, M=distant metastasis) in the… Expand There is now considerable direct evidence that tumor growth is angiogenesis–dependent1–4. The most compelling evidence is based… Expand BACKGROUND
Patients with head-and-neck cancers who are free of disease after local therapy remain at high risk for both recurrent… Expand