FAQ

precorrin-2 dehydrogenase activity

Known as: precorrin-2:NAD+ oxidoreductase activity, dihydrosirohydrochlorin dehydrogenase activity, precorrin-2 oxidase activity 
Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin. [EC:1.3.1.76, RHEA:15616]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2018
01219932018

Papers overview

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2006
2006
Requirement of Staphylococcus aureus ATP-binding cassette-ATPase FhuC for iron-restricted growth and evidence that it functions with more than one iron transporter.
In Staphylococcus aureus, fhuCBG encodes an ATP-binding cassette (ABC) transporter that is required for the transport of iron(III… (More)
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2004
2004
Involvement of SirABC in iron-siderophore import in Staphylococcus aureus.
Staphylococcus aureus SirA was previously identified as a lipoprotein, and SirB and SirC are thought to encode the transmembrane… (More)
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2003
2003
Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megaterium.
In Bacillus megaterium, the hemAXBCDL genes were isolated and were found to be highly similar to the genes from Bacillus subtilis… (More)
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2003
2003
CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis
Sulfur metabolism depends on the iron-containing porphinoid siroheme. In Salmonella enterica, the S-adenosyl-L-methionine (SAM… (More)
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2002
2002
The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase.
Sirohaem is a tetrapyrrole-derived prosthetic group that is required for the essential assimilation of sulfur and nitrogen into… (More)
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1999
1999
A HilA-independent pathway to Salmonella typhimurium invasion gene transcription.
Salmonella typhimurium invasion of nonphagocytic cells requires the expression of a type III secretion system (TTSS) encoded… (More)
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1997
1997
A role for Salmonella typhimurium cbiK in cobalamin (vitamin B12) and siroheme biosynthesis.
The role of cbiK, a gene found encoded within the Salmonella typhimurium cob operon, has been investigated by studying its in… (More)
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1996
1996
Evidence that the CysG protein catalyzes the first reaction specific to B12 synthesis in Salmonella typhimurium, insertion of cobalt.
The cysG gene of Salmonella typhimurium is involved in synthesis of both cobalamin (B12) and siroheme (a cofactor required for… (More)
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1994
1994
Gene dissection demonstrates that the Escherichia coli cysG gene encodes a multifunctional protein.
The C-terminus of the Escherichia coli CysG protein, consisting of amino acids 202-457, was expressed as a recombinant protein… (More)
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1993
1993
The Escherichia coli cysG gene encodes the multifunctional protein, siroheme synthase.
Previously, the E. coli cysG gene product had been shown to sequentially methylate uro'gen III to produce precorrin-2, hence it… (More)
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