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pradefovir
Known as:
9-(2-(4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl)methoxyethyl)adenine
, Remofovir
A cyclodiester antiviral prodrug with specific activity against hepatitis B virus (HBV). Pradefovir is specifically metabolized in the liver by…
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National Institutes of Health
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Related topics
Related topics
5 relations
Broader (2)
Adenine
Organophosphorus Compounds
Narrower (2)
MB 06866
pradefovir mesylate
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Safety, pharmacokinetics and pharmacogenetics of a single ascending dose of pradefovir, a novel liver-targeting, anti-hepatitis B virus drug, in healthy Chinese subjects
Yanhua Ding
,
Hong Zhang
,
+5 authors
J. Niu
Hepatology International
2017
Corpus ID: 9327526
AbstractBackgroundPradefovir is efficiently converted to adefovir [9-(2-phosphonylmethoxyethyl) adenine (PMEA)], producing high…
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2016
2016
Factors limiting the extent of absolute bioavailability of pradefovir in rat
Q. Xiao
,
Wanqiu Yang
,
+4 authors
Jin Yang
Xenobiotica; the fate of foreign compounds in…
2016
Corpus ID: 46362122
Abstract 1. Pradefovir was designed as an oral liver target prodrug of 9-(2-phosphonylmethoxyethyl) adenine (PMEA). Liver…
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Review
2010
Review
2010
A Review of Oral Antiretroviral Therapy for the Treatment of Chronic Hepatitis B
L. Hynicka
,
N. Yunker
,
P. H. Patel
The Annals of Pharmacotherapy
2010
Corpus ID: 22828134
Objective: To describe the current evidence for the use of oral antiretroviral (ARV) agents in the treatment of chronic hepatitis…
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2008
2008
Nuevos tratamientos para el manejo de la Hepatitis B
Federico Salom-Macaya
2008
Corpus ID: 193430534
2007
2007
Pradefovir, a liver-targeted prodrug of adefovir against HBV infection.
H. Tillmann
Current opinion in investigational drugs
2007
Corpus ID: 43092749
Metabasis Therapeutics Inc (previously Ribapharm Inc) is developing pradefovir, an oral liver-targeting prodrug of adefovir…
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2006
2006
36 Pharmacokinetics and pharmacodynamics of pradefovir, a liver-targeting prodrug of PMEA in HBV patients
C. Lin
,
C. Xu
,
L. Yeh
,
J. Sullivan-Bolyai
,
Y. Xu
2006
Corpus ID: 71239788
2006
2006
Pradefovir a promising prodrug for hepatitis B
S. Sullivan
2006
Corpus ID: 72332027
Review
2005
Review
2005
Clinical trial results of new therapies for HBV: implications for treatment guidelines.
R. Gish
Seminars in liver disease (Print)
2005
Corpus ID: 45683359
Currently approved treatments for chronic infection with hepatitis B virus (HBV) are limited by low rates of sustained response…
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2004
2004
5th Antiviral Drug Discovery & Development Summit
W. Blair
,
M. Perros
2004
Corpus ID: 72563272
The 5th Antiviral Drug Discovery and Development Summit provided an up-to-date snapshot of the ongoing developments in the area…
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2004
2004
5th Antiviral Drug Discovery and Development Summit.
W. Blair
,
M. Perros
Expert Opinion on Investigational Drugs
2004
Corpus ID: 39565946
The 5th Antiviral Drug Discovery and Development Summit provided an up-to-date snapshot of the ongoing developments in the area…
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