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ponesimod

Known as: (2Z,5Z)-5-(3-chloro-4-((2R)-2,3-dihydroxypropoxy)phenylmethylidene)-3-(2-methylphenyl)-2-(propylimino)-1,3-thiazolidin-4-one, 5-(3-chloro-4-(2,3-dihydroxy-propoxy)benzylidene)-2-propylimino-3-o-tolyl-thiazolidin-4-one 
An orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Objective This double-blind, placebo-controlled, dose-finding phase IIb study evaluated the efficacy and safety of ponesimod, an… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND We assessed the efficacy, safety, and tolerability of ponesimod, an oral, selective, reversible modulator of… Expand
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Highly Cited
2013
Highly Cited
2013
AIMS This study investigated the tolerability, safety, pharmacokinetics and pharmacodynamics of ponesimod, a novel oral selective… Expand
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Highly Cited
2011
Highly Cited
2011
Lymphocyte exit from lymph nodes and their recirculation into blood is controlled by the sphingolipid sphingosine 1-phosphate… Expand
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Highly Cited
2010
Highly Cited
2010
Sphingosine-1-phosphate (S1P) is a widespread lysophospholipid which displays a wealth of biological effects. Extracellular S1P… Expand
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Highly Cited
2010
Highly Cited
2010
2-acetylpyridine N(4)-phenyl thiosemicarbazone (H2Ac4Ph), and its N(4)-ortho-tolyl (H2Ac4oT), N(4)-meta-tolyl (H2Ac4mT), N(4… Expand
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2009
2009
The pro-catalysts [V(NAr)(L)(OR)] (Ar = p-tolyl, p-ClC(6)H(4), p-(OMe)C(6)H(4), p-(CF(3))C(6)H(4); R = t-Bu, i-Pr, n-Pr, Et, C(CH… Expand
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Highly Cited
2008
Highly Cited
2008
Transition-metal complexes capable of mediating multielectron transformations are critical components for a variety of small… Expand
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Highly Cited
2008
Highly Cited
2008
Enantiomerically pure methyl Norphos (A), tolyl Norphos (B), CF(3) Norphos (C), methyl Renorphos (D), and tolyl Renorphos (E… Expand
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Highly Cited
2007
Highly Cited
2007
As a continuation to our previous work concerning antitumor benzimidazoles, we have synthesized series of new derivatives of 2-(1… Expand
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