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ponesimod

Known as: (2Z,5Z)-5-(3-chloro-4-((2R)-2,3-dihydroxypropoxy)phenylmethylidene)-3-(2-methylphenyl)-2-(propylimino)-1,3-thiazolidin-4-one, 5-(3-chloro-4-(2,3-dihydroxy-propoxy)benzylidene)-2-propylimino-3-o-tolyl-thiazolidin-4-one 
An orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating… 
National Institutes of Health

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ACT 128800

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Thiazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
The antidepressant-like activity of nicotine, but not of 3-furan-2-yl-N-p-tolyl-acrylamide, is regulated by the nicotinic receptor β4 subunit
2011
2011
Synthesis of C-Pseudonucleosides Bearing Thiazolidin-4-one as a Novel Potential Immunostimulating Agent.
Several novel C-pseudonucleosides bearing thiazolidin-4-one were synthesized by one-pot three-component condensation using… 
2009
2009
Vanadium-based imido-alkoxide pro-catalysts bearing bisphenolate ligands for ethylene and epsilon-caprolactone polymerisation.
The pro-catalysts [V(NAr)(L)(OR)] (Ar = p-tolyl, p-ClC(6)H(4), p-(OMe)C(6)H(4), p-(CF(3))C(6)H(4); R = t-Bu, i-Pr, n-Pr, Et, C(CH… 
2008
2008
Reactivity of silole within a core-modified porphyrin environment: synthesis of 21-silaphlorin and its conversion to carbacorrole.
Condensation of 1,1-dimethyl-3,4-diphenyl-2,5-bis(p-tolylhydroxymethyl)silole with pyrrole and p-tolylaldehyde did not form the… 
2007
2007
[3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a Novel, Stereoselective, High-Affinity Antagonist Is a Useful Radioligand for the Human Transient Receptor Potential Vanilloid…
1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-yl-urea (A-778317) is a novel, stereoselective, competitive antagonist that… 
2005
2005
Design, Synthesis, and Analysis of a Polyethelene Glycol-Modified (PEGylated) Small Molecule Inhibitor of Integrin α4β1 with Improved Pharmaceutical Properties
Integrin α4β1 plays an important role in inflammatory processes by regulating the migration of leukocytes into inflamed tissues… 
2004
2004
Binuclear rhenium(I) complexes with bridging [2.2]paracyclophane-diimine ligands: probing electronic coupling through pi-pi interactions.
Two pseudo-para substituted bis-diimino[2.2]paracyclophane ligands (4,16-bis(picolinaldimine)-[2.2]paracyclophane (BPPc) and 4,16… 
2002
2002
Clinical evaluation of etched porcelain onlays: a 4-year report.
  • N. BarghiT. Berry
  • Compendium of continuing education in dentistry
  • 2002
  • Corpus ID: 23523974
Etched porcelain-bonded-to-enamel restorations (porcelain veneers) have demonstrated a low incidence of debonding, fracture… 
2000
2000
Experimental Evidence for Negative Hyperconjugation as a Component of the Polar Effect: Variation of the Ease of α-Sulfonyl Carbanion Formation with the Orientation of a β-Alkoxy Substituent
We report evidence for a strongly geometry-dependent substituent effect. The rate constants for H-D exchange of the R-hydrogens… 
1953
1953
The clinical results of oral and parenteral administration of 2-(N'p-tolyl-N'-m-hydroxyphenylaminomethyl) imidazoline hydrochloride (regitine) in the treatment of hypertension and an evaluation of…
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