ponesimod

Known as: (2Z,5Z)-5-(3-chloro-4-((2R)-2,3-dihydroxypropoxy)phenylmethylidene)-3-(2-methylphenyl)-2-(propylimino)-1,3-thiazolidin-4-one, 5-(3-chloro-4-(2,3-dihydroxy-propoxy)benzylidene)-2-propylimino-3-o-tolyl-thiazolidin-4-one 
An orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2011-2017
0246820112017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Ponesimod, a novel selective sphingosine-1-phosphate 1 receptor modulator in the development for the treatment of autoimmune… (More)
  • figure 1
  • figure 2
  • figure 2
Is this relevant?
2015
2015
Ponesimod is an orally active selective sphingosine-1-phosphate receptor 1 modulator under investigation for the treatment of… (More)
Is this relevant?
2015
2015
1. Ponesimod [(R)-5-[3-chloro-4-(-2,3-dihydroxy-propoxy)-benzylidene]-2-propylimino-3-o-tolyl-thiazolidin-4-one] is an orally… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
2014
2014
OBJECTIVE This double-blind, placebo-controlled, dose-finding phase IIb study evaluated the efficacy and safety of ponesimod, an… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • table 2
Is this relevant?
2014
2014
BACKGROUND We assessed the efficacy, safety, and tolerability of ponesimod, an oral, selective, reversible modulator of… (More)
Is this relevant?
2014
2014
This multiple-ascending-dose study investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ponesimod, an… (More)
Is this relevant?
2014
2014
Ponesimod (ACT-128800), a reversible, orally active, selective S1P1 receptor modulator, prevents the egress of lymphocytes from… (More)
  • table 1
  • table 2
  • table 3
  • figure 1
  • figure 2
Is this relevant?
2013
2013
AIMS This study investigated the tolerability, safety, pharmacokinetics and pharmacodynamics of ponesimod, a novel oral selective… (More)
Is this relevant?
2013
2013
To determine the effects of steady-state concentrations of the selective S1P1 receptor modulator ponesimod on the… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • table 2
Is this relevant?
2011
2011
Lymphocyte exit from lymph nodes and their recirculation into blood is controlled by the sphingolipid sphingosine 1-phosphate… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?