polyglutamine

Known as: poly(glutamine), polyQ 
 
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
The causes of amyotrophic lateral sclerosis (ALS), a devastating human neurodegenerative disease, are poorly understood, although… (More)
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Highly Cited
2007
Highly Cited
2007
ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
Expanded polyglutamine 72 repeat (polyQ72) aggregates induce endoplasmic reticulum (ER) stress-mediated cell death with caspase… (More)
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Highly Cited
2004
Highly Cited
2004
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Huntington disease is one of nine inherited neurodegenerative disorders caused by a polyglutamine tract expansion. Expanded… (More)
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Highly Cited
2003
Highly Cited
2003
Prospective identification of tumorigenic breast cancer cells
NEUROSCIENCE. For the article ‘‘Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded… (More)
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Highly Cited
2002
Highly Cited
2002
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.
Protein conformational disorders (PCDs), such as Alzheimer's disease, Huntington's disease (HD), Parkinson's disease and… (More)
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Highly Cited
2002
Highly Cited
2002
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.
Expansion of CAG trinucleotide repeats that encode polyglutamine is the underlying cause of at least nine inherited human… (More)
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Highly Cited
2001
Highly Cited
2001
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
Proteins with expanded polyglutamine repeats cause Huntington's disease and other neurodegenerative diseases. Transcriptional… (More)
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Highly Cited
1999
Highly Cited
1999
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
At least eight inherited human neurodegenerative diseases are caused by expansion of a polyglutamine domain within the respective… (More)
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Highly Cited
1998
Highly Cited
1998
Ataxin-1 Nuclear Localization and Aggregation Role in Polyglutamine-Induced Disease in SCA1 Transgenic Mice
Transgenic mice carrying the spinocerebellar ataxia type 1 (SCA1) gene, a polyglutamine neurodegenerative disorder, develop… (More)
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Highly Cited
1997
Highly Cited
1997
Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo
The mechanism by which an elongated polyglutamine sequence causes neurodegeneration in Huntington's disease (HD) is unknown. In… (More)
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