phosphoserine binding

The 14-3-3-related protein SMG7 plays critical roles in regulation of DNA damage response and nonsense-mediated mRNA decay (NMD… Expand

Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance pathway that recognizes mRNAs with premature stop codons and… Expand

Our previous study showed that Akt phosphorylates TopBP1 at the Ser-1159 residue and induces its oligomerization. Oligomerization… Expand

MOTIVATION Human Nbs1 and its homolog Xrs2 in Saccharomyces cerevisiae are part of the conserved MRN complex (MRX in yeast) which… Expand

The force exerted by blood as it flows through the vessels influences the development of atherosclerosis. An understanding of how… Expand

Phosphoserine-binding modules help determine the specificity of signal transduction events. One such module, the group IV WW… Expand

PAR-1 kinases are required to determine the anterior-posterior (A-P) axis in C. elegans and Drosophila, but little is known about… Expand

Phosphorylation of Smad1 at the conserved carboxyl terminal SVS sequence activates BMP signaling. Here we report the crystal… Expand

14-3-3 proteins are a family of multifunctional phosphoserine binding molecules that can serve as effectors of survival signaling… Expand

We have characterized a phosphoserine binding domain in the coactivator CREB-binding protein (CBP) which interacts with the… Expand