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phosphoribosylaminoimidazolecarboxamide formyltransferase activity

Known as: 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity, 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity, AICAR transformylase activity 
Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5… Expand
National Institutes of Health

Papers overview

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2010
2010
Abstract 4542: The design, synthesis andin vitroevaluation of selective FR α and β and PCFT substrates with potent GARFTase inhibitory activity as antitumor agents
Three folate transporters, the reduced folate carrier (RFC), folate receptors (FR) and the proton-coupled folate transporter… Expand
Highly Cited
2004
Highly Cited
2004
Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.
AICAR transformylase (5-aminoimidazole-4-carboxamide ribonucleotide transformylase) is a folate-dependent activity of the… Expand
1999
1999
Design, synthesis and evaluation of novel 6-arylsulfonylamino-3-chlorobenzo thiophene-2-carboxyamides Potent, lipophilic inhibitors of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase
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