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phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

Known as: 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity, MMAC1, phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity 
Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate. [EC:3.1.3.67]
National Institutes of Health

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Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatasephosphatidylinositol-3,4-bisphosphate 4-phosphatase

Papers overview

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2007
2007
The Expression and Significance of MMAC1 in Cystitis Glandularis and Bladder Transitional Cell Carcinoma
Purpose To investigate the expression of mutated in multiple advanced cancer (MMAC1) in cystitis glandularis and bladder… 
2007
2007
MMAC tumor supressor gene expression in ovarian endometriosis and ovarian adenocarcinoma.
OBJECTIVE The aim of this study was to investigate the role of MMAC1 protein in the relationship between ovarian endometriosis… 
2006
2006
Primary malignant lymphoma of the brain: analysis of MMAC1 (PTEN) tumor suppressor gene
With the use of RT-PCR (reverse transcriptase-polymerase chain reaction), Northern blot analysis, and Western blot analysis… 
Highly Cited
2000
Highly Cited
2000
The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity
Loss of the tumor suppressor MMAC1 has been shown to be involved in breast, prostate and brain cancer. Consistent with its… 
1999
1999
Mutation analysis of the putative tumor suppression gene PTEN/MMAC1 in sporadic breast cancer
PTEN/MMAC1, a potential human tumor suppressor gene, has been found to have inactivating mutations in several types of cancer… 
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