phenylacetyl disulfide

National Institutes of Health

Papers overview

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2016

2016

Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the generation of the sulfurising agent from phenylacetyl disulfide (PADS).

James L Scotson, Benjamin I. Andrews, Andrew P. Laws, Michael I. Page
Organic & biomolecular chemistry
2016

The synthesis of phosphorothioate oligonucleotides is often accomplished in the pharmaceutical industry by the sulfurisation of… (More)

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2016

2016

Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the sulfurisation of phosphites by phenylacetyl disulfide (PADS).

James L Scotson, Benjamin I. Andrews, Andrew P. Laws, Michael I. Page
Organic & biomolecular chemistry
2016

In the pharmaceutical industry the sulfurisation of nucleotide-phosphites to produce more biologically stable thiophosphates is… (More)

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2011

2011

Sulfurization of dinucleoside phosphite triesters with chiral disulfides.

Joshua A Mukhlall, William H. Hersh
Nucleosides, nucleotides & nucleic acids
2011

Sixteen chiral analogues of phenylacetyl disulfide (PADS) and 5-methyl-3H-1,2,4-dithiazol-3-one (MEDITH) were used to sulfurize… (More)

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2007

2007

An alternative advantageous protocol for efficient synthesis of phosphorothioate oligonucleotides utilizing phenylacetyl disulfide (PADS).

R. Krishna Kumar, Phil D Olsen, V. Ravikumar
Nucleosides, nucleotides & nucleic acids
2007

Phosphorothioate oligonucleotides could be synthesized using a 0.2 M solution of phenylacetyl disulfide (PADS) in a mixture of… (More)

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2006

2006

Development of siRNA for therapeutics: efficient synthesis of phosphorothioate RNA utilizing phenylacetyl disulfide (PADS).

V. Ravikumar, Mark Andrade, Recaldo L Carty, Amy A Dan, Steve Barone
Bioorganic & medicinal chemistry letters
2006

Efficient synthesis of phosphorothioate RNA (PS-RNA) is demonstrated by using phenylacetyl disulfide (PADS) in a mixture of… (More)

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2003

2003

Solid phase synthesis of phosphorothioate oligonucleotides utilizing diethyldithiocarbonate disulfide (DDD) as an efficient sulfur transfer reagent.

Zacharia S Cheruvallath, R. Krishna Kumar, C. -O. Rentel, Douglas L. Cole, V. Ravikumar
Nucleosides, nucleotides & nucleic acids
2003

Diethyldithiodicarbonate (DDD), a cheap and easily prepared compound, is found to be a rapid and efficient sulfurizing reagent in… (More)

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