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peptidyltransferase activity

Known as: peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity 
Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). [EC:2.3.2.12, PMID:11433365, PMID:9242921]
National Institutes of Health

Papers overview

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2004
2004
Biochemical evidence of translational infidelity and decreased peptidyltransferase activity by a sarcin/ricin domain mutation of yeast 25S rRNA.
A C-->U mutation (rdn5) in the conserved sarcin/ricin domain of yeast 25S rRNA has been shown to cause translational suppression… 
2003
2003
Catalytic Properties of Mutant 23 S Ribosomes Resistant to Oxazolidinones*
Kinetic analysis of ribosomal peptidyltransferase activity in a methanolic puromycin reaction with wild type and drug-resistant… 
1995
1995
Growth phase and growth rate dependence of ribosomal peptidyltransferase activity status in Escherichia coli.
1990
1990
Effect of nucleotide substitution on the peptidyltransferase activity of 2'(3')-O-(aminoacyl) oligonucleotides.
Seven 2'(3')-O-(aminoacyl) trinucleotides with structures derived from the 3'-terminal C-C-A sequence of aa-tRNA via nucleotide… 
1986
1986
Two monoclonal antibodies against Escherichia coli ribosomal protein L2 distinguish different locations for their respective epitopes in intact ribosomes.
1983
1983
The role of protein L16 and its fragments in the peptidyltransferase activity of 50-S ribosomal subunits.
Two large polypeptide fragments of ribosomal protein L16 were obtained by limited hydrolysis with trypsin and chymotrypsin. The… 
1981
1981
Functional organization of the large ribosomal subunit of Bacillus stearothermophilus.
1980
1980
The modification of the peptidyltransferase activity of 50-S ribosomal subunits, LiCl-split proteins and L16 ribosomal protein by pyridoxal phosphate.
Pyridoxal phosphate photoinactivates the peptidyltransferase activity of 50-S ribosomal subunits, LiCl split proteins and protein… 
Highly Cited
1973
Highly Cited
1973
A protein involved in the peptidyltransferase activity of Escherichia coli ribosomes.
Cores were prepared from 50S ribosomal subunits by incubation with 0.4 M LiCl/Mg(++) (0.4c cores); 0.8c cores and corresponding… 
Highly Cited
1972
Highly Cited
1972
Isolation of active ribosomal subunits from yeast.
We have designed a method for the large scale isolation of pure and highly active subunits from yeast cytoplasmic ribosomes. The… 
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