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peptide deformylase

 
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Messenger-RNA-directed protein synthesis is accomplished by the ribosome. In eubacteria, this complex process is initiated by a… Expand
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Highly Cited
2007
Highly Cited
2007
New classes of antibiotics are urgently needed to counter increasing levels of pathogen resistance. Peptide deformylase (PDF) was… Expand
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2006
2006
ABSTRACT Peptide deformylase (PDF) catalyzes the hydrolytic removal of the N-terminal formyl group from nascent proteins. This is… Expand
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Highly Cited
2003
Highly Cited
2003
Ribosomal protein synthesis in eubacteria and eukaryotic organelles initiates with an N-formylmethionyl-tRNA(i), resulting in N… Expand
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Highly Cited
2002
Highly Cited
2002
ABSTRACT Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth and is a new target for… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT Peptide deformylase (PDF) is an essential bacterial metalloenzyme which deformylates the N-formylmethionine of newly… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT New inhibitors of peptide deformylase (PDF) which are very potent against the isolated enzyme and show a certain degree… Expand
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Highly Cited
2000
Highly Cited
2000
Peptide deformylase (PDF) is essential in prokaryotes and absent in mammalian cells, thus making it an attractive target for the… Expand
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Highly Cited
2000
Highly Cited
2000
Low-molecular-weight beta-sulfonyl- and beta-sulfinylhydroxamic acid derivatives have been synthesized and found to be potent… Expand
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1998
1998
Peptide deformylase catalyzes the removal of the N-formyl group from newly synthesized polypeptides in prokaryotes. Its essential… Expand
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