peptide deformylase
National Institutes of Health
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Bacteriophages encode auxiliary metabolic genes that support more efficient phage replication. For example, cyanophages carry…
Two highly hydroxylated 1,3-dihydroisobenzofurans, FR198248 (1) and FR202306 (2), were isolated as peptide deformylase (PDF…
Bacterial peptide deformylase (PDF) represents a novel class of mononuclear iron peptidase, and has an intriguing metal…
AbstractComparative quantitative structure–activity relationship (QSAR) analyses of peptide deformylase (PDF) inhibitors were…
A peptide-cleaving catalyst selective for peptide deformylase (PDF) was obtained from a library containing about 15 000 catalyst…
Peptide deformylase is an attractive target for developing novel antibiotics. Previous studies at pH 3.0 showed peptide…
OBJECTIVE
BB-81384, a novel peptide deformylase (PDF) inhibitor, was characterized in terms of enzyme inhibition profile…
ABSTRACT Bacterial protein synthesis starts with a formylated methionine residue, and this residue is sequentially cleaved away…
ABSTRACT The activities of six peptide deformylase (PDF) inhibitors against 107 respiratory tract pathogens were studied and…
Identifying potential ligand binding sites on a protein surface is an important first step for targeted structure‐based drug…