pan-RAF Inhibitor LXH254

Known as: LXH254, LXH 254, pan-RAF Kinase Inhibitor LXH254

An orally available inhibitor of all members of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon…

National Institutes of Health

Papers overview

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2019

RAS mutant tumors have proven largely refractory to inhibitors of the MAPK pathway in clinic. In contrast, selective inhibitors…