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pafenolol

National Institutes of Health

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Propanolamines

Papers overview

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2004
2004
Regional Gastrointestinal Absorption of the Beta-Blocker Pafenolol in the Rat and Intestinal Transit Rate Determined by Movement of 14C-Polyethylene Glycol (PEG) 4000
The gastrointestinal absorption characteristics of pafenolol following oral administration as a solution in man and rat has… 
Highly Cited
2001
Highly Cited
2001
A comprehensive account on the role of efflux transporters in the gastrointestinal absorption of 13 commonly used substrate drugs in humans.
BACKGROUND The potential absorption-limiting effect of intestinal efflux transporters such as P-glycoprotein (P-gp) has been well… 
Highly Cited
1993
Highly Cited
1993
Evidence for an Interaction Between the β-Blocker Pafenolol and Bile Salts in the Intestinal Lumen of the Rat Leading to Dose-Dependent Oral Absorption and Double Peaks in the Plasma Concentration…
Pafenolol is a β-blocker with unusual oral absorption properties. The blood concentration–time profile exhibits two peaks, and… 
1993
1993
Dose-Dependent Intestinal Absorption and Significant Intestinal Excretion (Exsorption) of the β-Blocker Pafenolol in the Rat
The elimination of [3H]pafenolol and metabolites was investigated in fasted and fed rats. Separate groups received intravenous… 
1993
1993
Presystemic elimination of the beta-blocker pafenolol in the rat after oral and intraperitoneal administration and identification of a main metabolite in both rats and humans.
Pafenolol is a beta 1-adrenoreceptor antagonist exhibiting some interesting oral absorption properties in both rat and humans… 
1992
1992
Mediation of contraction and relaxation by alpha- and beta-adrenoceptors in the ureterovesical junction of the sheep.
1990
1990
Pharmacokinetics of a Single Intravenous and Oral Dose of Pafenolol—a Beta1Adrenoceptor Antagonist with Atypical Absorption and Disposition Properties—in Man
The pharmacokinetics of pafenolol were studied in eight young healthy individuals. The doses were 10 mg iv and 40 mg orally. Each… 
1990
1990
Pharmacokinetics of pafenolol after i.v. and oral administration of three separate doses of different strength to man.
The pharmacokinetics of pafenolol were evaluated in 12 healthy subjects after administration of three single IV doses (5, 10, and… 
1986
1986
β-Adrenergic control of motility in the rat colon. II. Proportions of β1- and β2-adrenoceptors identified with 125I-(−)pindolol binding
1983
1983
Pafenolol, a highly selective β1‐adrenoceptor–antagonist, in asthmatic patients: Interaction with terbutaline
Pafenolol, a new β1‐adrenoceptor antagonist, has been shown in animals to be more selective for β1‐adrenoceptors than metoprolol… 
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