paclitaxel metabolic process

Known as: paclitaxel metabolism 
The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment. [CHEBI:45863, GOC:jl]
National Institutes of Health

Papers overview

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2015
2015
Drug-drug Interaction between Losartan and Paclitaxel in Human Liver Microsomes with Different CYP2C8 Genotypes.
The cytochrome P450 (CYP) 2C8*3 allele is associated with reduced metabolic activity of paclitaxel. This study was aimed to… (More)
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2015
2015
A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory…
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that… (More)
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2014
2014
Carboplatin plus paclitaxel scheduling for advanced ovarian cancer - authors' reply.
e250 www.thelancet.com/oncology Vol 15 June 2014 with 7% in MITO-7, and grade 3–4 anaemia occurred in 44% of patients in NOVEL… (More)
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2013
2013
P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.
Paclitaxel is avidly transported by P-glycoprotein (P-gp/MDR1/ABCB1). This results in low oral bioavailability, which can be… (More)
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2011
2011
Influence of Cremophor EL and genetic polymorphisms on the pharmacokinetics of paclitaxel and its metabolites using a mechanism-based model.
The formulation vehicle Cremophor EL has previously been shown to affect paclitaxel kinetics, but it is not known whether it also… (More)
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2006
2006
Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer.
OBJECTIVE Paclitaxel is one of the most important anticancer drugs for the treatment of various tumors such as non-small cell… (More)
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Highly Cited
2001
Highly Cited
2001
Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism.
By sequencing genomic DNA from 73 established cell lines derived from Japanese individuals, we detected 9 single nucleotide… (More)
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Review
1997
Review
1997
Hepatic metabolism of paclitaxel and its impact in patients with altered hepatic function.
Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has been demonstrated to be an active anticancer agent, including… (More)
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1995
1995
Pretreatment H2 receptor antagonists that differ in P450 modulation activity: comparative effects on paclitaxel clearance rates and neutropenia
Histamine-2 receptor antagonists (H2RAs) are principal components of the premedication regimen used to prevent major… (More)
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1995
1995
Pretreatment H2 receptor antagonists that differ in P450 modulation activity: comparative effects on paclitaxel clearance rates and neutropenia
 Histamine-2 receptor antagonists (H2RAs) are principal components of the premedication regimen used to prevent major… (More)
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