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paclitaxel metabolic process

Known as: paclitaxel metabolism 
The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment. [CHEBI:45863, GOC:jl]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Abstract 5031: Distribution of single nucleotide polymorphisms related to paclitaxel and carboplatin toxicity in ovarian cancer patients
Introduction: Standard first-line treatment for ovarian cancer consists in the combined use of taxanes and platinum, with… 
2014
2014
Carboplatin plus paclitaxel scheduling for advanced ovarian cancer - authors' reply.
2012
2012
Abstract PD10-07: Patients carrying CYP2C8*3 are at increased risk of paclitaxel-induced neuropathy
Background: Paclitaxel-induced neuropathy is a common, severe adverse event that seems to be related to cumulative drug exposure… 
2011
2011
CORRECTION TO “Influence of Cremophor EL and Genetic Polymorphisms on the Pharmacokinetics of Paclitaxel and Its Metabolites Using a Mechanism-Based Model”
In the article referenced above [Fransson MN, Green H, Litton J-E, and Friberg LE (2011) Drug Metab Dispos 39: [247–255][1]], in… 
2006
2006
Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer
Highly Cited
2001
Highly Cited
2001
Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism.
By sequencing genomic DNA from 73 established cell lines derived from Japanese individuals, we detected 9 single nucleotide… 
Review
1997
Review
1997
Hepatic metabolism of paclitaxel and its impact in patients with altered hepatic function.
Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has been demonstrated to be an active anticancer agent, including… 
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