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paclitaxel metabolic process
Known as:
paclitaxel metabolism
The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment. [CHEBI:45863, GOC:jl]
National Institutes of Health
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2017
2017
Abstract 5031: Distribution of single nucleotide polymorphisms related to paclitaxel and carboplatin toxicity in ovarian cancer patients
M. Cordova
,
M. Bravo
,
+10 authors
G. Owen
2017
Corpus ID: 79900583
Introduction: Standard first-line treatment for ovarian cancer consists in the combined use of taxanes and platinum, with…
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2014
2014
Carboplatin plus paclitaxel scheduling for advanced ovarian cancer - authors' reply.
S. Pignata
,
M. Di Maio
,
C. Gallo
,
F. Perrone
The Lancet Oncology
2014
Corpus ID: 29758165
2012
2012
Abstract PD10-07: Patients carrying CYP2C8*3 are at increased risk of paclitaxel-induced neuropathy
D. Hertz
,
E. Dees
,
+5 authors
L. Carey
2012
Corpus ID: 71830529
Background: Paclitaxel-induced neuropathy is a common, severe adverse event that seems to be related to cumulative drug exposure…
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2011
2011
CORRECTION TO “Influence of Cremophor EL and Genetic Polymorphisms on the Pharmacokinetics of Paclitaxel and Its Metabolites Using a Mechanism-Based Model”
Experimental Therapeutics
2011
Corpus ID: 100378060
In the article referenced above [Fransson MN, Green H, Litton J-E, and Friberg LE (2011) Drug Metab Dispos 39: [247–255][1]], in…
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2006
2006
Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer
Y. Nakajima
,
T. Yoshitani
,
+15 authors
J. Sawada
Clinical pharmacology and therapy
2006
Corpus ID: 22096811
Highly Cited
2001
Highly Cited
2001
Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism.
A. Soyama
,
Yoshiro Saito
,
+7 authors
J. Sawada
Biological and Pharmaceutical Bulletin
2001
Corpus ID: 26143495
By sequencing genomic DNA from 73 established cell lines derived from Japanese individuals, we detected 9 single nucleotide…
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Review
1997
Review
1997
Hepatic metabolism of paclitaxel and its impact in patients with altered hepatic function.
Vrn Panday
,
M. Huizing
,
+4 authors
J. Beijnen
Seminars in Oncology
1997
Corpus ID: 8223584
Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has been demonstrated to be an active anticancer agent, including…
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