paclitaxel metabolic process

Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that… Expand

The cytochrome P450 (CYP) 2C8*3 allele is associated with reduced metabolic activity of paclitaxel. This study was aimed to… Expand

e250 www.thelancet.com/oncology Vol 15 June 2014 with 7% in MITO-7, and grade 3–4 anaemia occurred in 44% of patients in NOVEL… Expand

Paclitaxel is avidly transported by P‐glycoprotein (P‐gp/MDR1/ABCB1). This results in low oral bioavailability, which can be… Expand

Background: Paclitaxel-induced neuropathy is a common, severe adverse event that seems to be related to cumulative drug exposure… Expand

The formulation vehicle Cremophor EL has previously been shown to affect paclitaxel kinetics, but it is not known whether it also… Expand

Paclitaxel is one of the most important anticancer drugs for the treatment of various tumors such as non‐small cell lung cancer… Expand

Histamine-2 receptor antagonists (H2RAs) are principal components of the premedication regimen used to prevent major… Expand

By sequencing genomic DNA from 73 established cell lines derived from Japanese individuals, we detected 9 single nucleotide… Expand

Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has been demonstrated to be an active anticancer agent, including… Expand