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paclitaxel metabolic process

Known as: paclitaxel metabolism 
The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment. [CHEBI:45863, GOC:jl]
National Institutes of Health

Papers overview

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2015
2015
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that… Expand
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2015
2015
The cytochrome P450 (CYP) 2C8*3 allele is associated with reduced metabolic activity of paclitaxel. This study was aimed to… Expand
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2014
2014
e250 www.thelancet.com/oncology Vol 15 June 2014 with 7% in MITO-7, and grade 3–4 anaemia occurred in 44% of patients in NOVEL… Expand
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Highly Cited
2013
Highly Cited
2013
Paclitaxel is avidly transported by P‐glycoprotein (P‐gp/MDR1/ABCB1). This results in low oral bioavailability, which can be… Expand
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2012
2012
Background: Paclitaxel-induced neuropathy is a common, severe adverse event that seems to be related to cumulative drug exposure… Expand
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2011
2011
The formulation vehicle Cremophor EL has previously been shown to affect paclitaxel kinetics, but it is not known whether it also… Expand
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2006
2006
Paclitaxel is one of the most important anticancer drugs for the treatment of various tumors such as non‐small cell lung cancer… Expand
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2004
2004
Histamine-2 receptor antagonists (H2RAs) are principal components of the premedication regimen used to prevent major… Expand
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Highly Cited
2001
Highly Cited
2001
By sequencing genomic DNA from 73 established cell lines derived from Japanese individuals, we detected 9 single nucleotide… Expand
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Review
1997
Review
1997
Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has been demonstrated to be an active anticancer agent, including… Expand
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