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paclitaxel metabolic process

Known as: paclitaxel metabolism 
The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment. [CHEBI:45863, GOC:jl]
National Institutes of Health

Papers overview

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2015
2015
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that… Expand
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2015
2015
The cytochrome P450 (CYP) 2C8*3 allele is associated with reduced metabolic activity of paclitaxel. This study was aimed to… Expand
2014
2014
e250 www.thelancet.com/oncology Vol 15 June 2014 with 7% in MITO-7, and grade 3–4 anaemia occurred in 44% of patients in NOVEL… Expand
Highly Cited
2013
Highly Cited
2013
Paclitaxel is avidly transported by P‐glycoprotein (P‐gp/MDR1/ABCB1). This results in low oral bioavailability, which can be… Expand
2011
2011
The formulation vehicle Cremophor EL has previously been shown to affect paclitaxel kinetics, but it is not known whether it also… Expand
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Review
2007
Review
2007
Paclitaxel is one of the most widely used and effective anticancer drugs. Paclitaxel's clinical utility spans many tumor sites… Expand
2006
2006
Paclitaxel is one of the most important anticancer drugs for the treatment of various tumors such as non‐small cell lung cancer… Expand
2004
2004
Histamine-2 receptor antagonists (H2RAs) are principal components of the premedication regimen used to prevent major… Expand
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Highly Cited
2001
Highly Cited
2001
By sequencing genomic DNA from 73 established cell lines derived from Japanese individuals, we detected 9 single nucleotide… Expand
Review
1997
Review
1997
Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has been demonstrated to be an active anticancer agent, including… Expand