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ozolinone

Known as: 3-methyl-4-oxo-5-piperidinothiazolidine-2-ylidine acetic acid 
A loop diuretic and active metabolite of its prodrug etozoline. Ozolinone was never marketed.
National Institutes of Health

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Broader (2)

DiureticsThiazoles

Papers overview

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2004
2004
Pharmacodynamics and kinetics of etozolin/ozolinone in hypertensive patients with normal and impaired kidney function
SummaryThe effect on urinary electrolyte excretion, renin release and plasma norepinephrine of single oral doses of 400 mg… 
1994
1994
Vascular effects of loop diuretics: an in vivo and in vitro study in the rat
The vascular effects of loop diuretics were studied in two models designed to eliminate hemodynamic repercussions linked to… 
1986
1986
Chloride transport inhibition by various types of loop diuretics in fish opercular epithelium.
Isolated opercular epithelia of killifish (Fundulus heteroclitus), mounted in an Ussing chamber, were used to study the effects… 
1985
1985
Quantitative evaluation of ototoxic side effects of furosemide, piretanide, bumetanide, azosemide and ozolinone in the cat — a new approach to the problem of ototoxicity
SummaryA new method for the quantitative assessment of acute ototoxic side effects of drugs in described. It is suitable for… 
1984
1984
Effect of captopril on intrarenal blood flow.
1982
1982
Stereospecific inhibition by ozolinone of stimulated chloride secretion in rabbit colon descendens
SummaryThe effects of the diuretic drug ozolinone on electrogenic Cl− secretion by rabbit colonic mucosa were investigated in… 
1980
1980
Studies with the optically active isomers of the new diuretic drug ozolinone
The renal actions of the optically active isomers of the new diuretic drug ozolinone were studied by clearance, flowmeter and… 
1980
1980
Assay of etozolin and its main metabolite, ozolinone, in plasma by high performance liquid chromatography.
A sensitive and specific method for the determination of the diuretic Ethyl (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2… 
1978
1978
Effects of ozolinone, a diuretic active metabolite of etozoline, on renal function
SummaryThe renal action of 3-methyl-4-oxo-5-piperidino-thiazolidine-2-ylidine (ozolinone), a metabolite of the diuretic etozoline… 
1978
1978
Effects of ozolinone, a diuretic active metabolite of etozoline, on renal function
SummaryThe effects of ozolinone (3-methyl-4-oxo-5-piperidino-thiazolidine-2-ylidene) on renal tubular and glomerular functions… 
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