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orotidylic acid
Known as:
5-(dihydrogen phosphate)orotidine
, orotidine 5'-monophosphate
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Uridine Monophosphate
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
A role for flexible loops in enzyme catalysis.
M. Malabanan
,
T. L. Amyes
,
J. Richard
Current Opinion in Structural Biology
2010
Corpus ID: 10055041
Highly Cited
2000
Highly Cited
2000
Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase.
N. Wu
,
Y. Mo
,
J. Gao
,
E. Pai
Proceedings of the National Academy of Sciences…
2000
Corpus ID: 1888885
Orotidine 5'-monophosphate decarboxylase catalyzes the conversion of orotidine 5'-monophosphate to uridine 5'-monophosphate, the…
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Highly Cited
2000
Highly Cited
2000
Anatomy of a proficient enzyme: the structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog.
B. Miller
,
A. Hassell
,
R. Wolfenden
,
M. Milburn
,
S. Short
Proceedings of the National Academy of Sciences…
2000
Corpus ID: 29815872
Orotidine 5'-phosphate decarboxylase produces the largest rate enhancement that has been reported for any enzyme. The crystal…
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Highly Cited
2000
Highly Cited
2000
Remarkable rate enhancement of orotidine 5'-monophosphate decarboxylase is due to transition-state stabilization rather than to ground-state destabilization.
A. Warshel
,
M. Strajbl
,
J. Villá
,
J. Florián
Biochemistry
2000
Corpus ID: 45036447
The remarkable rate enhancement of orotidine 5'-phosphate decarboxylase (ODCase) has been attributed to ground-state…
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Highly Cited
2000
Highly Cited
2000
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase.
T. Appleby
,
C. Kinsland
,
T. Begley
,
S. Ealick
Proceedings of the National Academy of Sciences…
2000
Corpus ID: 26013803
The crystal structure of Bacillus subtilis orotidine 5'-monophosphate (OMP) decarboxylase with bound uridine 5'-monophosphate has…
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2000
2000
Determination of the mechanism of orotidine 5'-monophosphate decarboxylase by isotope effects.
M. Rishavy
,
W. Cleland
Biochemistry
2000
Corpus ID: 22998317
Orotidine 5'-monophosphate shows a (15)N isotope effect of 1.0036 at N-1 for decarboxylation catalyzed by orotidine 5…
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Highly Cited
1997
Highly Cited
1997
A proficient enzyme revisited: the predicted mechanism for orotidine monophosphate decarboxylase.
J. K. Lee
,
K. Houk
Science
1997
Corpus ID: 25235541
A mechanism is proposed to explain the activity of orotidine 5'-monophosphate decarboxylase (ODCase). This enzyme is the one of…
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Highly Cited
1975
Highly Cited
1975
Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5…
P. Reyes
,
M. Guganig
Journal of Biological Chemistry
1975
Corpus ID: 30902768
Review
1970
Review
1970
Regulation of pyrimidine and arginine biosynthesis in mammals.
M. E. Jones
Advances in Enzyme Regulation
1970
Corpus ID: 20968844
Highly Cited
1959
Highly Cited
1959
The biochemical activity of 6-azauridine: interference with pyrimidine metabolism in transplantable mouse tumors.
C. Pasternak
,
R. Handschumacher
Journal of Biological Chemistry
1959
Corpus ID: 22964886
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