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orotidylic acid

Known as: 5-(dihydrogen phosphate)orotidine, orotidine 5'-monophosphate 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Uridine Monophosphate
analogs & derivatives

Papers overview

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2011
2011
Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.
The efficacy of most marketed antimalarial drugs has been compromised by evolution of parasite resistance, underscoring an urgent… Expand
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Review
2010
Review
2010
A role for flexible loops in enzyme catalysis.
Triosephosphate isomerase (TIM), glycerol 3-phosphate dehydrogenase, and orotidine 5'-monophosphate decarboxylase each use the… Expand
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2005
2005
Activation of orotidine 5'-monophosphate decarboxylase by phosphite dianion: the whole substrate is the sum of two parts.
We report that the binding of phosphite dianion to orotidine 5'-monophosphate decarboxylase (OMPDC) results in an 80 000-fold… Expand
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Review
2003
Review
2003
Catalysis by enzyme conformational change as illustrated by orotidine 5'-monophosphate decarboxylase.
  • Jiali Gao
  • Current opinion in structural biology
  • 2003
    • Corpus ID: 24933744
An energy decomposition scheme has been used to elucidate the importance of the changes of enzyme conformational substates to the… Expand
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Highly Cited
2000
Highly Cited
2000
Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase.
Orotidine 5'-monophosphate decarboxylase catalyzes the conversion of orotidine 5'-monophosphate to uridine 5'-monophosphate, the… Expand
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2000
2000
Anatomy of a proficient enzyme: the structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog.
Orotidine 5'-phosphate decarboxylase produces the largest rate enhancement that has been reported for any enzyme. The crystal… Expand
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2000
2000
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase.
The crystal structure of Bacillus subtilis orotidine 5'-monophosphate (OMP) decarboxylase with bound uridine 5'-monophosphate has… Expand
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Highly Cited
1998
Highly Cited
1998
Altered expression of selectable marker URA3 in gene-disrupted Candida albicans strains complicates interpretation of virulence studies.
The ura-blaster technique for the disruption of Candida albicans genes has been employed in a number of studies to identify… Expand
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1981
1981
Biochemical programs of slowly and rapidly growing human colon carcinoma xenografts.
Abstract The purpose of this investigation was to elucidate the enzymic programs of pyrimidine, carbohydrate, and purine… Expand
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1975
1975
Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5…
A pyrimidine phosphoribosyltransferase, previously shown to utilize 5-fluorouracil and possibly also uracil and orotate (Reyes, P… Expand
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