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ophiocordin

Known as: Benzoic acid, 4-(2-(((hexahydro-4-((4-hydroxybenzoyl)oxy)-1H-azepin-3-yl)amino)carbonyl)-6-hydroxybenzoyl)-3,5-dihydroxy-, balanol 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Antibiotics, AntifungalAzepinesHydroxybenzoates

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Recent chemoenzymatic total syntheses of natural and unnatural products: Codeine, balanol, pancratistatin, and oseltamivir
Presented here is a short summary of the recent accomplishments in total synthesis in our laboratories. In particular, recent… 
Highly Cited
2005
Highly Cited
2005
Molecular docking of balanol to dynamics snapshots of protein kinase A
Even if the structure of a receptor has been determined experimentally, it may not be a conformation to which a ligand would bind… 
2004
2004
Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit.
The protein kinase family is a prime target for therapeutic agents, since unregulated protein kinase activities are linked to… 
2002
2002
Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits.
A series of analogues of the protein kinase C (PKC) inhibitory natural product balanol which bear modified benzophenone subunits… 
2001
2001
Computational analysis of PKA-balanol interactions.
Protein kinases are important targets for designing therapeutic drugs. This paper illustrates a computational approach to extend… 
Review
1999
Review
1999
Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development.
Protein kinase C (PKC) is a family of enzymes that play a ubiquitous role in intracellular signal transduction. Our understanding… 
Highly Cited
1999
Highly Cited
1999
Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase.
Endogenous protein kinase inhibitors are essential for a wide range of physiological functions. These endogenous inhibitors may… 
Highly Cited
1999
Highly Cited
1999
Determinants of ligand binding to cAMP-dependent protein kinase.
Protein kinases are essential for the regulation of cellular growth and metabolism. Since their dysfunction leads to debilitating… 
1999
1999
Asymmetric synthesis of the balanol heterocycle via a palladium-mediated epimerization and olefin metathesis.
[formula: see text] The enantioselective formal synthesis of balanol, a potent protein kinase C inhibitor, was accomplished from… 
1995
1995
Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol.
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